The effect of tibolone versus 17 beta-estradiol on climacteric symptoms in women with surgical menopause: A randomized, cross-over study
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Dosyalar
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To compare the effectiveness of tibolone and 17 beta-estradiol on climacteric symptoms, in a randomized, single-blind, cross-over study in surgically menopausal women. Material and methods: Forty surgically menopausal women were divided randomly into two groups. Group A received treatment with tibolone for 6 months, while group B received 17 beta-estradiol. After 3 weeks washout period, treatment protocols were exchanged for another 6 months. The climacteric symptoms were assessed with Greene Climacteric Scale at baseline, during washout and after the treatments. Statistical analysis was done with the Wilcoxon's Sign Rank test. Results: Both treatments significantly improved the scores of all subscales with respect to baseline. However, the improvement in psychological, somatic and sexual subscales were significantly superior in the tibolone group compared with 17 beta-estradiol group. Both treatments showed comparable improvements in the relief of vasomotor symptoms. Conclusion: Our findings suggest that tibolone may improve mood, libido and somatic symptoms in surgically menopausal women to a greater extent than estrogen therapy alone. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Surgical menopause, Tibolone, 17 beta-estradiol, Greene Climacteric Scale
Kaynak
Maturitas
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
56
Sayı
1
