Evaluation of chromosomal abnormalities and common trombophilic mutations in cases with recurrent miscarriage
dc.contributor.author | Karataş, Ahmet | |
dc.contributor.author | Eröz, Recep | |
dc.contributor.author | Albayrak, Mustafa | |
dc.contributor.author | Özlü, Tülay | |
dc.contributor.author | Çakmak, Bülent | |
dc.date.accessioned | 2021-06-23T19:36:51Z | |
dc.date.available | 2021-06-23T19:36:51Z | |
dc.date.issued | 2014 | |
dc.department | BAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.description.abstract | Background: Recurrent miscarriage (RM) is a frequent obstetric problem. Its' pathophysiology is poorly understood. Infections, genetic, endocrine, anatomic and immunologic problems have been suggested as causes for RM. Objective: To evaluate the frequency of chromosomal abnormalities and 3 common thrombophilic mutations in couples with RM. Methods: A retrospective data collection was performed for the results of the cytogenetic analysis of the couples and Methylenetetrahydrofolate Reductase (MTHFR) C677T, Factor V Leiden (FVL) G1691A and Prothrombin (PTm) G20210A mutations of the mother in 142 couples suffering from RM. Results: Prevalence of FVL, MTHFR, and PTm gene mutations were similar between cases shaving 2 or >= 3 abortions (P=0.528; P=0.233; P=0.375). In patients with FVL, MTHFR and PTm gene mutations, the OR's of having >= 3 abortions when compared to having 2 abortions were 1.515 (95% CI: 0.414-5.552), 0.573 (95% CI: 0.228-1.441), and 2.848 (95% CI: 0.355-22.871). All cases with PTm mutation had >= 3 abortions and all abortions occurred between 6-8 gestational weeks. Conclusion: Chromosomal abnormalities and thrombophilic mutations (especially PTm) seem to have an important role in RM. Additional larger studies involving investigation of more genes that may have a role in pregnancy are needed to assess this association. | en_US |
dc.identifier.doi | 10.4314/ahs.v14i1.34 | |
dc.identifier.endpage | 222 | en_US |
dc.identifier.issn | 1680-6905 | |
dc.identifier.issn | 1729-0503 | |
dc.identifier.issue | 1 | en_US |
dc.identifier.pmid | 26060483 | en_US |
dc.identifier.scopus | 2-s2.0-84896091201 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 216 | en_US |
dc.identifier.uri | https://doi.org/10.4314/ahs.v14i1.34 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12491/8064 | |
dc.identifier.volume | 14 | en_US |
dc.identifier.wos | WOS:000335444500034 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.institutionauthor | Karataş, Ahmet | |
dc.language.iso | en | en_US |
dc.publisher | Makerere Univ, Fac Med | en_US |
dc.relation.ispartof | African Health Sciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Recurrent Miscarriage | en_US |
dc.subject | Chromosomal Abnormalities | en_US |
dc.subject | Inherited Thrombophilic Polymorphisms | en_US |
dc.title | Evaluation of chromosomal abnormalities and common trombophilic mutations in cases with recurrent miscarriage | en_US |
dc.type | Article | en_US |
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