Effects of long term low dose acrylamide exposure on rat bone marrow polychromatic erythrocytes

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dc.contributor.authorYener, Yeşim
dc.date.accessioned2021-06-23T19:34:23Z
dc.date.available2021-06-23T19:34:23Z
dc.date.issued2013
dc.departmentBAİBÜ, Eğitim Fakültesi, Eğitim Bilimleri Bölümüen_US
dc.description.abstractI investigated whether long term low dose exposure to acrylamide increased micronucleus frequency in rat bone marrow polychromatic erythrocytes (PCEs). Twenty-five male and 25 female Wistar rats were used. Animals of each sex were segregated into two treatment groups and one control group. Each treatment group consisted of ten animals and each control group consisted of five animals. Acrylamide, 2 or 5 mg/kg/day, was administered to the treatment groups in their drinking water for 90 days. Twenty-four hours after the last treatment, bone marrow samples were obtained and analyzed for the frequency of micronucleated polychromatic erythrocytes (MNPCEs). The cytotoxic effect of acrylamide on bone marrow also was tested by assessing the polychromatic erythrocyte/normochromatic erythrocyte (PCE/NCE) ratio. Both doses of acrylamide significantly increased the frequency of MNPCEs in both male and female rats. Acrylamide also decreased the PCE/NCE ratio in both sexes compared to the control group. My study showed that chronic low dose exposure to acrylamide increased the formation of micronuclei in PCEs of male and female rat bone marrow.en_US
dc.identifier.doi10.3109/10520295.2013.790561
dc.identifier.endpage360en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue6en_US
dc.identifier.pmid23672417en_US
dc.identifier.scopus2-s2.0-84880370488en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage356en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2013.790561
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7493
dc.identifier.volume88en_US
dc.identifier.wosWOS:000321905400011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYener, Yeşim
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcrylamideen_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectMicronucleusen_US
dc.subjectRaten_US
dc.titleEffects of long term low dose acrylamide exposure on rat bone marrow polychromatic erythrocytesen_US
dc.typeArticleen_US

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