Relationship between Prostate Size and Positive Surgical Margin in the Open Radical Prostatectomy Surgery
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Our study aims to reveal the correlation between positive surgical margins and prostate volume, thus determining a cutoff value for the prostate volume to predict PCM in patients with open radical prostatectomy.Methodology: In our study, a number of 450 patients who had undergone radical prostatectomy surgery at 2 centers within the last 5 years was evaluated. Age, total PSA, number of positive cores for prostate cancer, Gleason score, transfusion amount and prostate volume were all evaluated in the study. Evaluated all these parameters, 170 consecutive patients of whom data were available were included in the studyResults: Stage T3 and PSA>10 ng/dL were statistically significant for positive surgical margins (p=0,002 and p<0,001, respectively). The number of positive cores and Gleason score from these biopsies was also statistically higher in those with positive surgical margins (p=0,002 and p<0,001, respectively). In the multivariate logistic regression analysis, the risk for PCM was found to be 2.67 times higher in patients with PSA>10 ng/dL (95% CI: 1.18 to 6.04; p = 0.018) and stage T3 increased the risk for PCM by 8.51 times (95% CI: 3.54 to 20.51, p = <0.001). When we performed AUROC analysis to determine the positivity of surgical margin in terms of prostate volume, we achieved a cutoff value of 34.5 with 55% sensitivity and 71% specificity (AUC: 0.646, 95% CI: 0.555 to 0.737, p = 0.002). Again, any value above 34.5 cc was found to statistically significantly increase the risk for PCM by 2.86 times (95% CI: 1.31 to 6.28; p = 0.009).Conclusion: We found that the prostate volume had an important role in positivity of surgical margins. It is likely that addition of prostate volume as well to nomograms used before surgery may be useful in improving of risk assessment in prostate cancer. Furthermore, evaluation of the prostate volume can be used as a prognostic factor for prostate cancer.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Acta Medica Anatolia
WoS Q Değeri
Scopus Q Değeri
Cilt
4
Sayı
3
