Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats
Yükleniyor...
Dosyalar
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Assoc Medica Brasileira
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
OBJECTIVE: We aimed to explore the effects of neuropeptides ghrelin, obestatin, and vasoactive intestinal peptide (VIP) on seizures and plasma concentrations of neuroinflammation biomarkers including calcitonin gene-related peptide (CGRP), substance-P (SP), and interleukin-1 beta (IL-1 beta) in pentylenetetrazol-induced seizures in rats. METHODS: Ghrelin (80 mu g/kg), obestatin (1 mu g/kg), VIP (25 ng/kg) or saline were administered to rats intraperitoneally 30 min before pentylenetetrazole (PTZ, 50 mg/kg) injections. Stages of epileptic seizures were evaluated by Racine's scale, and plasma CG RP, SP, and IL-1 beta concentrations were measured using ELISA. RESULTS: Both obestatin and VIP shortened onset-time of generalized tonic-clonic seizure, respectively, moreover VIP also shortened the onset-time of first myoclonic-jerk induced by PTZ. While PTZ increased plasma CG RP, SP and IL-1 beta concentrations, ghrelin reduced the increases evoked by PTZ. While VIP further increased PTZ-evoked CG RP levels, it diminished IL-1 beta concentrations. However, obestatin did not change CGRP, SR and IL-1 beta concentrations. CONCLUSION: Our results suggest that ghrelin acts as an anticonvulsant, obestatin acts as a proconvulsant, and VIP has dual action on epilepsy. Receptors of those neuropeptides may be promising targets for epilepsy treatment.
Açıklama
Anahtar Kelimeler
Epilepsy, Neuroinflammation, Ghrelin, Vasoactive Intestinal Peptide, Obestatin
Kaynak
Revista Da Associacao Medica Brasileira
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
65
Sayı
9