Modulatory effects of neuropeptides on pentylenetetrazol-induced epileptic seizures and neuroinflammation in rats

Yükleniyor...
Küçük Resim

Tarih

2019

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Assoc Medica Brasileira

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

OBJECTIVE: We aimed to explore the effects of neuropeptides ghrelin, obestatin, and vasoactive intestinal peptide (VIP) on seizures and plasma concentrations of neuroinflammation biomarkers including calcitonin gene-related peptide (CGRP), substance-P (SP), and interleukin-1 beta (IL-1 beta) in pentylenetetrazol-induced seizures in rats. METHODS: Ghrelin (80 mu g/kg), obestatin (1 mu g/kg), VIP (25 ng/kg) or saline were administered to rats intraperitoneally 30 min before pentylenetetrazole (PTZ, 50 mg/kg) injections. Stages of epileptic seizures were evaluated by Racine's scale, and plasma CG RP, SP, and IL-1 beta concentrations were measured using ELISA. RESULTS: Both obestatin and VIP shortened onset-time of generalized tonic-clonic seizure, respectively, moreover VIP also shortened the onset-time of first myoclonic-jerk induced by PTZ. While PTZ increased plasma CG RP, SP and IL-1 beta concentrations, ghrelin reduced the increases evoked by PTZ. While VIP further increased PTZ-evoked CG RP levels, it diminished IL-1 beta concentrations. However, obestatin did not change CGRP, SR and IL-1 beta concentrations. CONCLUSION: Our results suggest that ghrelin acts as an anticonvulsant, obestatin acts as a proconvulsant, and VIP has dual action on epilepsy. Receptors of those neuropeptides may be promising targets for epilepsy treatment.

Açıklama

Anahtar Kelimeler

Epilepsy, Neuroinflammation, Ghrelin, Vasoactive Intestinal Peptide, Obestatin

Kaynak

Revista Da Associacao Medica Brasileira

WoS Q Değeri

Q4

Scopus Q Değeri

N/A

Cilt

65

Sayı

9

Künye