Radyoterapiye ikincil gelişen beyin hasarı (Nekroz) ve bellek bozukluğu
Küçük Resim Yok
Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
70 yaşında, sağ elini kullanan erkek hasta; yakınları tarafından farkedilen durgunluk, dikkatsizlik ve konuşma bozukluğu şikayetleriyle nöroloji kliniğine getirildi. İlk muayenesinde apati hali ve oryantasyon problemi mevcuttu. Öz geçmişinde kavernöz sinüs menenjiomu tanısıyla 30 kür radyoterapi-gama knife tedavileri öyküsü olan hastanın kognitif muayenesinde yakın bellek kusuru saptanırken, görsel-mekansal işlevlerin ağır derecede bozuk olduğu görüldü. Magnetik Rezonanslı Görüntülemelerinde (MRG) menejiom ve bilateral temporal ve parietal loblarda fokal ve yaygın, geç dönem radyonekroz görünümüyle uyumlu, düzgün sınırlı olmayan lezyonlar izlendi. Magnetik Rezonanslı Spektroskopi (MRS) incelemesinde azalmış kolin düzeyleri rapor edildi. Radyonekroza ikincil gelişen bellek bozukluğu tanısıyla hastaneye yatırılan ve takibe alınan olgunun bilinç bozukluğunda artış görüldü. Hastaneye yatışını takibeden üç haftalık süreç sonunda hasta kaybedildi. Olgumuz, radyoterapiye ikincil komplikasyonların takibini vurgulamak ve kognitif fonksiyonların genelde korunmasına rağmen ; temporal lob yapısını etkileyen radyoterapinin bellek üzerindeki etkisini tartışmak amacıyla sunuldu.
A 70 year-old male patient with right hand dominance was seen at our neurology outpatient clinic because of dullness, carelessness and speech defeat complaints perceived by his relatives. At his primary examination, an apathetic state and orientation problem were noticed. There was a history of 30 radiotherapy-gamma knife therapies, for cavernous sinus menengioma and a recent memory defect was noticed at the cognitive examination of the patient while he had major difficulties with visual-spatial processing. MRI showed meningioma and focal and widespread bilateral lesions in temporal and parietal lobes with irregular borders conforming to late radionecrosis. Decreased choline levels were reported at MRS examination, on the other hand. The patient was hospitalised with a diagnosis of memorial ongoing disturbance secondary to radionecrosis. There was an ongoing impairment at his conciousness and deterioration was noticed during this time. The patient died 3 weeks after the hospitalisation. The aim of reporting this case is to reveal the importance of following complications secondary to radionecrosis and to discuss interference of memory after radiotherapy which effects temporal lobe structures although cognitive functions generally are spared at this procedures.
A 70 year-old male patient with right hand dominance was seen at our neurology outpatient clinic because of dullness, carelessness and speech defeat complaints perceived by his relatives. At his primary examination, an apathetic state and orientation problem were noticed. There was a history of 30 radiotherapy-gamma knife therapies, for cavernous sinus menengioma and a recent memory defect was noticed at the cognitive examination of the patient while he had major difficulties with visual-spatial processing. MRI showed meningioma and focal and widespread bilateral lesions in temporal and parietal lobes with irregular borders conforming to late radionecrosis. Decreased choline levels were reported at MRS examination, on the other hand. The patient was hospitalised with a diagnosis of memorial ongoing disturbance secondary to radionecrosis. There was an ongoing impairment at his conciousness and deterioration was noticed during this time. The patient died 3 weeks after the hospitalisation. The aim of reporting this case is to reveal the importance of following complications secondary to radionecrosis and to discuss interference of memory after radiotherapy which effects temporal lobe structures although cognitive functions generally are spared at this procedures.
Açıklama
Anahtar Kelimeler
Klinik Nöroloji, Nörolojik Bilimler
Kaynak
Anadolu Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
3
Sayı
3
