The effect of Anatolian syrup on experimentally induced acetaminophen and lipopolysaccharide associated acute kidney injury

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dc.contributor.authorDüzcü, Selma Erdoğan
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorEfe, Muhammet
dc.contributor.authorKayiş, Seyit Ali
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorYoldaş, Meyri Arzu
dc.contributor.authorTirink, Omer Faruk
dc.date.accessioned2024-09-25T20:24:03Z
dc.date.available2024-09-25T20:24:03Z
dc.date.issued2022
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractBackground: Acute kidney injury develops as a result of various etiologies and pathological mechanisms, with a high mortality rate. This study aimed to investigate the efficacy of Anatolian syrup on histopathological variables in experimentally induced acetaminophen and lipopolysaccharide associated acute kidney injury. Methods: In this study, 5 groups were formed using 40 male Wistar albino rats (200- 220g, 2-4 months old), as follows: Sham, acetaminophen (1 g/kg intraperitoneal (ip)), 3) lipopolysaccharide (5 mg/kg ip), acetaminophen (1 g/kg ip) + Anatolian syrup (15 days orally), and lipopolysaccharide (5 mg/kg ip) + Anatolian syrup (15 days orally).Tubular atrophy, tubular dilatation, cytoplasmic vacuolization in tubular epithelial cells, tubular epithelial cell necrosis, interstitial inflammation, congestion, hemorrhage, glomerular damage and loss of brushy border were evaluated histopathologically semiquantitatively using scoring from 0 to 5. Results: In histopathological variables, tubular atrophy, tubular dilatation, cytoplasmic vacuolization, necrosis, congestion, hemorrhage, glomerular damage, and loss of brushy border were significantly reduced in the acetaminophen + Anatolian syrup group compared to the acetaminophen group and in the lipopolysaccharide + Anatolian syrup group compared to the lipopolysaccharide group (p<0.001). Conclusions: The Anatolian syrup was shown to protect histopathological variables in kidney damage caused by acetaminophen and lipopolysaccharide.en_US
dc.identifier.doi10.54307/NWMJ.2022.65365
dc.identifier.endpage122en_US
dc.identifier.issn2757-7724
dc.identifier.issue2en_US
dc.identifier.startpage112en_US
dc.identifier.trdizinid1166588en_US
dc.identifier.urihttps://doi.org/10.54307/NWMJ.2022.65365
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1166588
dc.identifier.urihttps://hdl.handle.net/20.500.12491/16289
dc.identifier.volume2en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofNorthwestern Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleThe effect of Anatolian syrup on experimentally induced acetaminophen and lipopolysaccharide associated acute kidney injuryen_US
dc.typeArticleen_US

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