Deep brain stimulation in idiopathic Parkinson’s disease

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dc.contributor.authorTurel, Canan Akünal
dc.contributor.authorArican, Murat
dc.date.accessioned2024-09-25T20:24:04Z
dc.date.available2024-09-25T20:24:04Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractParkinson’s disease (PD) is the second most common neurodegenerative and progressive neurological disorder characterized by tremors, rigidity, bradykinesia, and postural instability. Changes of disease in PD pathophysiology are observed in melanin-containing dopaminergic cells in the substantia nigra. While neuronal loss and gliosis are observed in this region, the remaining neurons may contain cytoplasmic inclusions called Lewy bodies. Deep Brain Stimulation (DBS), is the method of application with the highest patient satisfaction among device-assisted treatments in advanced PD. The DBS method is frequently preferred in cases where the disease progresses, drug treatment does not respond, and freezing and on-off dyskinesias begin. The most preferred method among these is subthalamic nucleus (STN) DBS. DBS treatment improves not only motor symptoms but also non-motor symptoms. The success of DBS is based on adequate response to levodopa, appropriate patient selection, successful neuroanatomical and radiological localization of the target area, and a team experienced in motion sickness. Many studies are being conducted to understand the mechanism of action of deep brain stimulation, the effectiveness of which has been proven by various studies. The excitation and suppressive effects provided by the electrodes are processed with a complex neuronal network and clinical results are obtained. In this article, deep brain stimulation tricks, choosing appropriate patients, and mechanisms of action in Parkinson’s disease will be summarized.en_US
dc.identifier.doi10.54307/NWMJ.2023.ID
dc.identifier.endpage61en_US
dc.identifier.issn2757-7724
dc.identifier.issue1en_US
dc.identifier.startpage56en_US
dc.identifier.trdizinid1169875en_US
dc.identifier.urihttps://doi.org/10.54307/NWMJ.2023.ID
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1169875
dc.identifier.urihttps://hdl.handle.net/20.500.12491/16299
dc.identifier.volume3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofNorthwestern Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleDeep brain stimulation in idiopathic Parkinson’s diseaseen_US
dc.typeReview Articleen_US

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