Comparison of cerebral effects of thiopental and propofol infusion in traumatic brain injured rats

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dc.contributor.authorKiliccioğlu, Yıldıray
dc.contributor.authorYildiz, Isa
dc.contributor.authorYoldaş, Hamit
dc.contributor.authorKaragoz, Ibrahim
dc.contributor.authorTekçe, Buket Kin
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorBilgi, Murat
dc.date.accessioned2024-09-25T20:24:03Z
dc.date.available2024-09-25T20:24:03Z
dc.date.issued2022
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: Head trauma is a lethal, disabling, and pathological condition requiring long-term treatment and care. Thiopental and propofol infusions are frequently used for sedation in the intensive care unit (ICU). However, we do not have clear data on whether they are neuroprotective or neurotoxic. We aimed to compare the early cerebral effects of propofol and thiopental, which are used for sedation in acute head trauma. Methods: A total of 30 rats were included in this experimental study, and the animals were randomly divided into three groups; 5 ml/kg/h 0.9% dose NaCl infusion was given in the control group, 30 mg/kg/h dose propofol infusion was given in the propofol group, and 140 mcg/kg/h dose of thiopental infusion was given in the thiopental group. Blood samples were taken 4 hours after infusion. A craniotomy was performed, the brain was removed, and it was placed in 10% neutral formalin for histological examination. The materials were examined biochemically and histologically and then compared between the groups. Results: The S100B value between the groups was significantly lower in the thiopental group than in the control group (p=0.018). Tau protein levels were significantly lower in the propofol group than in the control group (p=0.07). In histological examinations, the number of apoptotic cells in the propofol and thiopental groups were significantly lower than in the control group (p=0.02). There was no significant difference between the propofol and thiopental groups in apoptotic cell numbers (p=0.3). Conclusion: Our study demonstrated that thiopental and propofol infusions following a head trauma reduced apoptotic cell death and caused a decrease in trauma markers.en_US
dc.identifier.doi10.54307/NWMJ.2022.14622
dc.identifier.endpage74en_US
dc.identifier.issn2757-7724
dc.identifier.issue2en_US
dc.identifier.startpage65en_US
dc.identifier.trdizinid1166578en_US
dc.identifier.urihttps://doi.org/10.54307/NWMJ.2022.14622
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1166578
dc.identifier.urihttps://hdl.handle.net/20.500.12491/16280
dc.identifier.volume2en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofNorthwestern Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleComparison of cerebral effects of thiopental and propofol infusion in traumatic brain injured ratsen_US
dc.typeArticleen_US

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