Investigation of the effect of quercetin in an experimental oxygen-induced retinopathy model

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dc.contributor.authorKaymaz, Abdulgani
dc.contributor.authorUlaş, Fatih
dc.contributor.authorErimşah, Sevilay
dc.contributor.authorÖztabag, Cansu Kara
dc.date.accessioned2024-09-25T20:18:25Z
dc.date.available2024-09-25T20:18:25Z
dc.date.issued2021
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: To investigate of the effect of intraperitoneal (IP) quercetin and bevacizumab on oxygen-inducedretinopathy (OIR) model in rats.Methods: In the study, 28 newborn rats were used. The OIR model was performed with the 50/10% oxygentechnique. The study consisted of four groups as a control group (Group I) and OIR groups (Group II, III, andIV). IP injection applied to all groups on the postnatal day (PND) 14. Groups I and II were performed 0.9%NaCl, Group III was performed IP bevacizumab, and Group IV was performed IP quercetin. All animals weresacrificed on PND 18.Results: Based on the data obtained from immunohistochemical and histopathological examinations, thenumber of vascular endothelial cell (VEC), vascular endothelial growth factor (VEGF), and tumor necrosisfactor-? (TNF-?) levels were significantly reduced in Group III and IV compared to Group II. VECs levelswere 0±0, 32.69±5.77, 2.92±0.63, and 3.64±0.36 in Group I, Group II, Group III, and Group IV, respectively(p<0.001). Likewise, VEGF values were 0.15±0.01, 7.57±1.80, 2.45±0.45, and 2.46±0.49, respectively(p<0.001). As well as TNF-? values were 0.06±0.01, 8.22±2.24, 2.32±0.32, and 2.29±0.26 in Group I, GroupII, Group III, and Group IV, respectively (p<0.001). There was no significant difference between Group IIIand Group IV in terms of VEC, VEGF and TNF-? values (range of p values was 0.96-1.00).Conclusion: The results of the present study showed that quercetin administration significantly reduced theVEC number and suppressed VEGF and TNF-?. Quercetin's anti-inflammatory and anti-angiogenesis effectwas found to be similar to bevacizumab.en_US
dc.identifier.doi10.30714/j-ebr.2021267976
dc.identifier.endpage140en_US
dc.identifier.issn2618-6454
dc.identifier.issue2en_US
dc.identifier.startpage131en_US
dc.identifier.trdizinid424356en_US
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2021267976
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/424356
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15666
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleInvestigation of the effect of quercetin in an experimental oxygen-induced retinopathy modelen_US
dc.typeArticleen_US

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