Evaluation of the effect of Carvacrol on retinal neovascularization in rats

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dc.contributor.authorKaymaz, Abdulgani
dc.contributor.authorErimşah, Sevilay
dc.date.accessioned2024-09-25T20:13:57Z
dc.date.available2024-09-25T20:13:57Z
dc.date.issued2021
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjectives: To compare the effect of intraperitoneal administered Carvacrol with bevacizumab in anoxygen-induced retinopathy (OIR) model in rats.Materials and Methods: Twenty-eight newborn rats were included in the study and the OIR model wascreated with the 50/10% oxygen style. The study consisted of 4 groups and each rat in the groups receivedan intraperitoneal injection of 0.01 mL once on the postnatal 14th day. While the OIR model was not createdin Group I (control group), it was created for Groups II, III, and IV. Groups I and II were injected with 0.9%NaCl solution, Group III with bevacizumab, and Group IV with carvacrol. The rats were sacrificed on thepostnatal 18th day.Results: Histopathological and immunohistochemical studies showed that the number of retinal vascularendothelial cells (RVECs) and nuclear factor (NF)-?B levels decreased similarly in Group III and Group IVcompared to Group II. RVECs values for Group I, Group II, Group III and Group IV were measured as1.26±0.80, 27.10±3.63, 7.54±1.38, and 6.22±1.22, respectively and it differed significantly between groups(p<0.001). Likewise, NF-?B levels were recorded as 0.61 ± 0.30, 4.36±0.65, 2.68±0.44, and 2.85±0.58,respectively and it differed significantly between groups (p<0.001). On the other hand, RVECs and NF-?Blevels were similar between Group III, and Group IV (p values were 0.58 and 0.91, respectively).Conclusions: The study demonstrated that carvacrol significantly reduced retinal pathologicalneovascularizations, RVECs, and NF-?B levels. Moreover, the observed effects were comparable to those ofbevacizumab.en_US
dc.identifier.doi10.47748/tjvr.878271
dc.identifier.endpage40en_US
dc.identifier.issn2602-3695
dc.identifier.issue1en_US
dc.identifier.startpage35en_US
dc.identifier.trdizinid439913en_US
dc.identifier.urihttps://doi.org/10.47748/tjvr.878271
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/439913
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14904
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Veterinary Research (Online)en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectNeovascularizationen_US
dc.subjectcarvacrolen_US
dc.subjectoxygen-induced retinopathyen_US
dc.subjectBevacizumaben_US
dc.subjectretinal vascular endothelial cellen_US
dc.subjectnuclear factor-?Ben_US
dc.titleEvaluation of the effect of Carvacrol on retinal neovascularization in ratsen_US
dc.typeArticleen_US

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