Evaluating the efficiency of different propofol doses associated with age and gender in rats

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dc.contributor.authorYildiz, Isa
dc.contributor.authorYoldaş, Hamit
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorÇakmak, Mücahit
dc.contributor.authorÇamsari, Çağrı
dc.contributor.authorAyaz, Erol
dc.date.accessioned2024-09-25T20:18:29Z
dc.date.available2024-09-25T20:18:29Z
dc.date.issued2022
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: To investigate the effect of different intraperitoneal (IP) doses of propofol on the duration and depth of anesthesia according to age and gender. Method: The rats were divided into three main groups according to propofol dose (GI: 5 mg/kg, GII: 10 mg/kg and GIII: 15 mg/kg). These three groups were divided into two subgroups as male and female. (M: Male, F: Female). Male and female groups in each dose group were divided into five different sub-age groups: 1: 2-6 months (0-12 years = Childhood), 2: 7-12 months (12-18 years = Adolescent), 3: 13-18 months (30-45 years = Young adult), 4: 19-24 months (45-60 years = Adult) and 5: older than 25 months (65 years old = Elderly). The duration and depth of anesthesia in different ages and genders were compared statistically. Results: There were differences with regard to the palpebral, pinch, corneal and muscle tone reflexes at propofol administration doses of 5 mg/kg (GI), 10 mg/kg (GII) and 15 mg/kg (GIII) in different ages and genders (Table 1). We detected that 50 minutes of deep anesthesia was achieved with a dose of 10 mg/kg up to 18 months and older than 24 months male rats. A dose of 10 mg/kg was sufficient for short-term (20-minute deep anesthesia) procedures in male rats aged 19-24 months. We detected that 50 minutes of deep anesthesia was achieved with a dose of 15 mg/kg in 7-12 and 13-18 month old female rats. A dose of 10 mg/kg dose was sufficient for short-term procedures in 0-6 month old female rats. However, only superficial anesthesia was detected at the dose of 15 mg/kg in female rats older than 18 months. Conclusion: The present study demonstrated that 10 or 15 mg/kg low doses of intraperitoneal propofol administration affected the duration and depth of anesthesia in different ages and genders in rats.en_US
dc.identifier.doi10.30714/j-ebr.2022.156
dc.identifier.endpage376en_US
dc.identifier.issn2618-6454
dc.identifier.issue4en_US
dc.identifier.startpage367en_US
dc.identifier.trdizinid1134121en_US
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2022.156
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1134121
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15686
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleEvaluating the efficiency of different propofol doses associated with age and gender in ratsen_US
dc.typeArticleen_US

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