Platelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodules

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dc.contributor.authorBilgin, Satilmis
dc.contributor.authorKahveci, Gizem
dc.contributor.authorTel, Burçin Meryem Atak
dc.contributor.authorKurtkulaği, Özge
dc.contributor.authorKösekli, Mehmet Ali
dc.date.accessioned2024-09-25T20:18:28Z
dc.date.available2024-09-25T20:18:28Z
dc.date.issued2021
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: Differentiation of thyroid nodules, either as benign or malignant, is a real diagnostic challenge.Inflammation has an important role in development of the malignancy. Therefore, inflammatory markers areassociated with malignant thyroid nodules. Platelet /lymphocyte ratio (PLR) is also one of the novelinflammatory indices derived from hemogram tests. We hypothesized whether PLR was associated withmalignant thyroid nodules. For this purpose, we compared PLR levels of the patients with benign thyroidnodules to the PLR of the subjects with malignant nodules.Methods: The subjects who visited outpatient internal medicine clinics of our institution with a diagnosis ofthyroid nodule were enrolled to the present retrospective study. According to the examination of the fine needleaspiration cytology (FNAC) specimen of the nodules, patients grouped into benign or malignant nodule groups.PLR of groups were compared.Results: Median PLR values of the benign and malignant thyroid nodule groups were 106 (48-432) % and 119(48-365) %, respectively (p=0.001). PLR value higher than 106% has 69% sensitivity and 51% specificity indetecting malignant nodules (AUC: 0.59, p=0.001, 95% CI: 0.54-0.65). PLR was positively correlated withTSH level (r=0.10, p=0.34).Conclusion: We suggest that elevated PLR could be an additional tool to differentiate malignant thyroidnodules from benign ones in supportive of sonography, scintigraphy and cytology.en_US
dc.identifier.doi10.30714/j-ebr.2021267978
dc.identifier.endpage153en_US
dc.identifier.issn2618-6454
dc.identifier.issue2en_US
dc.identifier.startpage148en_US
dc.identifier.trdizinid424544en_US
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2021267978
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/424544
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15668
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofExperimental Biomedical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titlePlatelet to lymphocyte ratio in differentiation of benign and malignant thyroid nodulesen_US
dc.typeArticleen_US

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