Efficacy of prophylactic calcium dobesilate in renal ischemia-reperfusion injury in rats

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dc.contributor.authorAkkoç, Ali
dc.contributor.authorMetin, Ahmet
dc.date.accessioned2024-09-25T20:15:20Z
dc.date.available2024-09-25T20:15:20Z
dc.date.issued2020
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: In this study, the objective was to investigate the protective effect of calcium dobesilate, which has antioxidant and anti-inflammatory properties, on the experimental renal ischemia-reperfusion injury (IRI). Methods: Twenty-four male Wistar-Albino rats were divided into three groups: Sham group (Group 1), ischemia-reperfusion group (Group 2), and treatment group (Group 3). Before the ischemia-reperfusion procedure, rats in Group 3 received calcium dobesilate through gavage (100mg/kg/day) for 10 days. Groups other than the sham group underwent ischemia for 45 minutes and reperfusion for 24 hours. Plasma urea and creatinine levels, erythrocyte superoxide dismutase and glutathione peroxidase enzyme activity levels were measured. In addition, histopathological changes that may be related to ischemia-reperfusion injury in the renal tissue, were investigated. Results: The median glutathione peroxidase and superoxide dismutase enzyme levels were higher in Group 2 compared to Groups 1 and 3. However, the differences were not statistically significant. The creatine levels were statistically lower in Group 3 compared to Group 1 and Group 2. The median urea levels were lower in Group 3 than in Group 1 and Group 2, but the differences were not statistically significant. The histopathological examination showed that parameters such as cellular necrosis, flattened tubular epithelial cells, cytoplasmic vacuolization, tubular lumen obstruction, and chronic inflammation, which are indicators of the ischemia-reperfusion injury, were statistically less common in the treatment group compared to the control group. Conclusion: Our study demonstrated that prophylactic calcium dobesilate had a protective effect on ischemia-reperfusion injury.en_US
dc.identifier.endpage174en_US
dc.identifier.issn2587-0319
dc.identifier.issue2en_US
dc.identifier.startpage169en_US
dc.identifier.trdizinid471807en_US
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/471807
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15108
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofActa Medica Alanyaen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleEfficacy of prophylactic calcium dobesilate in renal ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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