Antioxidant Properties of Myrtus Extract: in vitro Assays and in vivo Experimental Animal Study

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dc.contributor.authorDenk, Barış
dc.contributor.authorÖzçinar, Ümit
dc.contributor.authorÖzsandik, Ismail Hakkı
dc.contributor.authorShah, Syed Rizwan Ali
dc.contributor.authorÇetingül, Ibrahim Sadi
dc.contributor.authorÇalik, Ali
dc.contributor.authorMidilli, Mustafa
dc.date.accessioned2024-09-25T20:12:34Z
dc.date.available2024-09-25T20:12:34Z
dc.date.issued2024
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: The study explores Myrtus communis L. extract (ME) as a potential antioxidant agent in drinking water. It encompassed in vitro assays and in vivo tests on Wistar albino rats.Material and Methods: ME's antioxidant activity (AOA) was evaluated using metal chelating activity (MCA), reducing power (RP), and superoxide radical scavenging activity (SRSA) assays. In vivo experiments involved exposing rat groups to various ME concentrations (0, 1.25, 2.5, 3.75 ve 5 mL/cage). Redox parameters were analyzed in blood, liver, and kidney tissues, exploring treatment, gender, and redox marker interactions. Results: MCA showed the highest AOA at 0.1 mg/mL and the lowest at 0.4 mg/mL, while RP exhibited the opposite (p<0.05). The changes in SRSA levels were not statistically significant (p>0.05). Pearson correlation unveiled a strong negative link between RP and SRSA (p<0.05). MCA and RP showed a weaker, insignificant negative correlation, while MCA and SRSA displayed a moderate, little positive correlation (p<0.05). In vivo analysis highlighted interactions among treatment, gender, and redox markers. Total oxidant status (TOS) in blood was affected by the interaction of treatment and gender. TOS exhibited dose-dependent effects in blood, while other parameters (malondialdehyde, reduced glutathione, total antioxidant status) remained unchanged primarily (p<0.05). Conclusion: ME showed concentration-dependent antioxidant effects in vitro and in vivo. Although tissue redox balance was minimally affected, kidney GSH elevation indicated potential antioxidant benefits. This underscores ME's potential as a natural health supplement, urging further investigations for optimal doses and effects. The study highlights ME's potential in the food and pharmaceutical sectors.en_US
dc.identifier.doi10.5336/vetsci.2023-99249
dc.identifier.endpage8en_US
dc.identifier.issn2146-8850
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.trdizinid1239847en_US
dc.identifier.urihttps://doi.org/10.5336/vetsci.2023-99249
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1239847
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14542
dc.identifier.volume15en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTürkiye Klinikleri Veteriner Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAntioxidant potentialen_US
dc.subjectMyrtus communis L. extracten_US
dc.subjectin vitro assaysen_US
dc.subjectredoxen_US
dc.subjectWistar albino ratsen_US
dc.titleAntioxidant Properties of Myrtus Extract: in vitro Assays and in vivo Experimental Animal Studyen_US
dc.typeArticleen_US

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