P53 May Still a Reliable Marker in Determining the Prognosis of NonMuscle Urothelial Carcinomas
Küçük Resim Yok
Tarih
2015
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Dergi ISSN
Cilt Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Kas invaziv olmayan ürotelyal karsinomlarda grade, evre, rekürrens ve progresyon açısından p53 ekspresyonu incelenmiştir. Metod: Mesane kanseri nedeniyle yapılan ilk transüretral rezeksiyonu sonucunda pTa ve pT1 papiller ürotelyal kanser tanısı almış toplam 60 hasta retrospektif çalışmaya dahil edildi. İmmünohistokimyasal olarak tüm dokular p53 ile boyandı. Hastalar rekürrens ve progresyon göstermelerine göre iki gruba ayrıldı. Sonuçlar: Spearman’s korelasyon testine göre p53 ile tümör grade’i ve evresi arasında anlamlı ilişki vardı (r = 0.372 and 0.443, p < 0.001). Multivariate analiz’ e göre p53 rekürrensi göstermede tek başına bağımsız prediktördü (OR = 12.01, 95% CI = 1 16.6). Progresyonu göstermede bağımsız bir prediktör bulunamadı. Sonuç: p53, pTa ve pT1 ürotelyal karsinomlarda rekürrensi göstermede faydalı bir belirteç olabilir.
Objectives: We aimed to analysis immunostaining of p53 regarding to grade, stage, recurrence and progression in nonmuscle urotelial cancers (pTa and pT1 papillary tumors). Methods: A total of 60 patients undergoing their first transurethral resection for bladder cancer and newly diagnosed papillary urothelial carcinoma (pTa and pT1) were included in retrospective study. Immunohistochemically, all tissue sections were stained with p53. The patients were divided into two groups based on recurrence and progression. Results: Using Spearman’s correlation test, p53 was significantly positively correlated with tumor stage and tumor grade (r = 0.372 and 0.443, respectively; p < 0.001). Based on a multivariate analysis, p53 staining was found to be the only independent predictive factor for recurrence (OR = 12.01, 95% CI = 1 16.6) and no independent predictive factor for progression was found. Conclusions: p53 may be prove useful in predicting recurrence of pTa and pT1 urothelial cancers.
Objectives: We aimed to analysis immunostaining of p53 regarding to grade, stage, recurrence and progression in nonmuscle urotelial cancers (pTa and pT1 papillary tumors). Methods: A total of 60 patients undergoing their first transurethral resection for bladder cancer and newly diagnosed papillary urothelial carcinoma (pTa and pT1) were included in retrospective study. Immunohistochemically, all tissue sections were stained with p53. The patients were divided into two groups based on recurrence and progression. Results: Using Spearman’s correlation test, p53 was significantly positively correlated with tumor stage and tumor grade (r = 0.372 and 0.443, respectively; p < 0.001). Based on a multivariate analysis, p53 staining was found to be the only independent predictive factor for recurrence (OR = 12.01, 95% CI = 1 16.6) and no independent predictive factor for progression was found. Conclusions: p53 may be prove useful in predicting recurrence of pTa and pT1 urothelial cancers.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Acta Medica Anatolia
WoS Q Değeri
Scopus Q Değeri
Cilt
3
Sayı
1
