The Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early-Stage Non-Small Cell Lung Cancer

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dc.contributor.authorKavaş, Murat
dc.contributor.authorGürer, Deniz
dc.contributor.authorAlişik, Murat
dc.contributor.authorÖztürk, Akın
dc.contributor.authorBekir, Sümeyye Alparslan
dc.contributor.authorEroğlu, Selma Aydoğan
dc.contributor.authorErsöz, Elçin
dc.date.accessioned2024-09-25T20:24:05Z
dc.date.available2024-09-25T20:24:05Z
dc.date.issued2023
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: Lung cancer has a poor prognosis. Thiol groups with high antioxidant capacity are converted to disulfide bonds through biochemical reactions that neutralize different oxidant compounds. The thiol-disulfide (SH-SS) homeostasis has significant effects on cell mechanisms, transcription, and apoptosis. Here we present the prognostic role of dynamic SH-SS homeostasis in patients operated for NSCLC. Materials and Methods: Patients operating for early-stage NSCLC were prospectively analyzed. SH-SS homeostasis tests were measured using the automated spectrophotometric method. Results: This study enrolled 138 subjects, including 77 patients and 61 healthy controls. Native thiol and total thiol levels were significantly lower in the patient group. The disulfide-to-native thiol ratio, which is an indicator of oxidative stress in SH-SS homeostasis, also reached a level of statistical significance in the patient group (p<0.001). According to the cut-off values (305 and 326.3), the median overall survival rate was significantly shorter in patients with low native thiol and total thiol levels (p<0.001). Conclusions: This study demonstrated decreased native thiol and total thiol levels as well as decreased disulfide levels and SS/SH ratio in early-stage NSCLC. Impaired SH-SS homeostasis may contribute to lung cancer pathogenesis and poor prognosis because of enhanced oxidative stress.en_US
dc.identifier.doi10.26453/otjhs.1226101
dc.identifier.endpage126en_US
dc.identifier.issn2459-1467
dc.identifier.issue1en_US
dc.identifier.startpage122en_US
dc.identifier.trdizinid1158919en_US
dc.identifier.urihttps://doi.org/10.26453/otjhs.1226101
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1158919
dc.identifier.urihttps://hdl.handle.net/20.500.12491/16323
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofOnline Türk Sağlık Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectOxidative stressen_US
dc.subjectthiolen_US
dc.subjectdisulphideen_US
dc.subjectNSCLCen_US
dc.subjectearly stage lung canceren_US
dc.titleThe Effect of Thiol-Disulfide Homeostasis on Prognosis in Patients with Early-Stage Non-Small Cell Lung Canceren_US
dc.typeArticleen_US

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