Does smoking affect the Ki67 and p53 expressions in asymptomatic fully impacted lower third molar follicles?
Yükleniyor...
Dosyalar
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Ki67 and p53 protein expressions are the most widely used markers to show the pathologic proliferation and early-stage tumoral alterations in vital tissues. The aim of this study was to compare Ki67 and p53 protein expressions in smokers' and nonsmokers' pericoronal follicles of asymptomatic impacted lower third molars (ILTMs). Materials and Methods: A cross-sectional study was planned. The study sample was derived from a population of patients who presented for evaluation and operative treatment of asymptomatic ILTMs. The predictor variable was smoking status, defined as smoker or nonsmoker. Outcome variables were Ki67 and p53 protein expressions in ILTM follicles. Other study variables were age, gender, tooth position, cigarette pack-year, epithelial layer staining, and inflammation. Independent-samples t test analyses were conducted with SPSS 10.0 (SPSS, Inc, Chicago, IL), with statistical significance set at a P value equal to .05. Results: The study sample was composed of 70 patients (35 in the smoker group) who contributed 60 follicles. There were statistical differences between the 2 groups for variables Ki67 and p53. Mean expression levels of Ki67 were 3.93 +/- 2.17 and 2.48 +/- 2.09, respectively, for smokers and nonsmokers (P = .011). Mean expression levels of p53 were 5.32 +/- 1.98 and 3.06 +/- 2.34, respectively, for smokers and nonsmokers (P = .000). Conclusion: The present study showed that dental follicles of smokers have higher Ki67 and p53 protein expressions than nonsmokers' follicles. (c) 2015 American Association of Oral and Maxillofacial Surgeons
Açıklama
Anahtar Kelimeler
Kaynak
Journal Of Oral And Maxillofacial Surgery
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
73
Sayı
5
