Is there a relationship between polycystic ovary syndrome and the FABP1 gene rs2197076 single nucleotide polymorphism?

Aim: Polycystic ovary syndrome (PCOS) is a multifactorial, endocrine, and metabolic disorder seenin 10%-20% of women of reproductive age. Due to the close relationship observed between theincreased risk of type 2 diabetes and insulin resistance and the polymorphism of the fatty acid bindingprotein 1 (FABP1) gene rs2197076 single nucleotide polymorphism (SNP), we investigated thefrequency of the FABP1 gene rs2197076 SNP in patients with PCOS.Methods: This is a prospective case-control study. The study included 151 women—75 patients withPCOS and 76 healthy women. A real-time polymerase chain reaction was performed for the FABP1rs2197076 polymorphism. Additionally, biochemical and hormonal levels of the patients werestudied.Results: Menstrual irregularities, the body mass index (BMI), hirsutism scores, the luteinizinghormone / follicular stimulating hormone ratio, dehydroepiandrosterone sulfate and testosteronelevels were significantly higher in the PCOS group than in the control. There was no significantdifference between the PCOS and control groups in terms of FABP1 rs2197076 genotype distributionand FABP1 rs2197076 allele frequency distribution.Conclusion: There was no increase in the genotype distribution and allelic frequency of the FABP1 geners2197076 SNP in PCOS patients. Further studies are needed on this subject.