Synthesis of iPF(2 alpha)-V: a new route
Yükleniyor...
Dosyalar
Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We are reporting here on a new synthesis of iPF(2 alpha)-V, and we also disclose the first report on the synthesis of 12-epi-iPF(2 alpha)-V. The new total synthesis of iPF(2 alpha)-V reported here is designed to address metabolism and analytical issues. We have used this new route and also performed the total synthesis of 17,17,18,18-tetradeutero-iPF(2 alpha)-V. The availability of the deuterated analog of iPF(2 alpha)-V is the first step in our attempt to quantitate this isoprostane in biological fluids by GC and LC-MS.
Açıklama
Anahtar Kelimeler
Isoprostanes, Prostaglandins, Eicosanoids, iPF(2 alpha)-V, iPF(2 alpha)-VI
Kaynak
Tetrahedron Letters
WoS Q Değeri
Q2
Scopus Q Değeri
Q3
Cilt
40
Sayı
34
