Could Serum Copeptin Be Used for Diagnosing Urinary Tract Infections in Children?

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dc.contributor.authorBekdaş, Mervan
dc.contributor.authorErkocoglu, Mustafa
dc.contributor.authorKarabörk, Şeyda
dc.contributor.authorDilek, Mustafa
dc.date.accessioned2024-09-25T20:23:58Z
dc.date.available2024-09-25T20:23:58Z
dc.date.issued2022
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: Early diagnosis of urinary tract infection (UTI) is important to reduce short- and long-term complications. To this end, effective biomarkers\rare needed. Our aim was to evaluate the role of copeptin in the diagnosis of UTI and in distinguishing upper from lower UTI compared to other\rinflammatory markers.\rMethods: The diagnosis of UTI was based on the presence of typical clinical symptoms and a positive urine culture. The control group was formed by\rhealthy children without signs or symptoms of infection. Complete blood count, CRP, ESR, serum IL -6, NGAL and copeptin were evaluated.\rResults: The study group included 41 patients with UTI and 41 healthy controls. The patients were 5 (0.8-15) years old and 65.9% of them were female.\rIn the patients with UTI, in addition to total WBC (p<0.001) and NGAL (p=0.031), copeptin was also increased (147.9(60.8-361.9) vs. 69.7(24.2-303) ng/\rml, p<0.001). Copeptin could diagnose UTI at a cut-off value of 81.8 ng/ml (p<0.001, sensitivity 80.4%, specificity 60.5%). Within the UTI group, 10 had\rupper UTI and 31 had lower UTI. In the upper UTI group WBC (p=0.019), CRP (p<0.001), ESR (p<0.001) and NGAL (p=0.046) were higher. Copeptin did\rnot differ between upper and lower UTI groups (p=0.82). Copeptin correlated with IL -6 and NGAL (r²=0.23, p=0.002; r²=0.89, p<0.001, respectively).\rConclusion: Copeptin is a useful biomarker to use in the diagnosis of childhood UTI, but more comprehensive studies are needed to evaluate its role\rin distinguishing upper from lower UTI.en_US
dc.identifier.doi10.17944/mkutfd.913838
dc.identifier.endpage17en_US
dc.identifier.issn2149-3103
dc.identifier.issue45en_US
dc.identifier.startpage12en_US
dc.identifier.trdizinid512727en_US
dc.identifier.urihttps://doi.org/10.17944/mkutfd.913838
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/512727
dc.identifier.urihttps://hdl.handle.net/20.500.12491/16254
dc.identifier.volume13en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMustafa Kemal Üniversitesi Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.subjectCopeptinen_US
dc.subjectUTIen_US
dc.subjectNGALen_US
dc.subjectIL-6en_US
dc.titleCould Serum Copeptin Be Used for Diagnosing Urinary Tract Infections in Children?en_US
dc.typeArticleen_US

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