Erdosteine protects rat testis tissue from hypoxic injury by reducing apoptotic cell death

dc.authorid0000-0002-1557-7019en_US
dc.authorid0000-0003-0290-5498
dc.contributor.authorGüven, Aysel
dc.contributor.authorİçkin, Meltem
dc.contributor.authorUzun, Özge
dc.contributor.authorBakar, Coşkun
dc.contributor.authorBalbay, Ege Güleç
dc.date.accessioned2021-06-23T19:36:23Z
dc.date.available2021-06-23T19:36:23Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe purpose of this study was to examine the effects of hypobaric hypoxia on testis morphology and the effects of erdosteine on testis tissue. Caspase-3 and hypoxia-inducible factor 1 expressions were detected by immunohistochemistry. Adult male Wistar rats were placed in a hypobaric hypoxic chamber. Rats in the erdosteine group were exposed to the same conditions and treated orally with erdosteine (20mgkg(-1) daily) at the same time from the first day of hypoxic exposure for 2weeks. The normoxia group was evaluated as the control. The hypoxia group showed decreased height of spermatogenic epithelium in some seminiferous tubules, vacuolisation in spermatogenic epithelial cells, deterioration and gaps in the basal membrane and an increase in blood vessels in the interstitial area. The erdosteine group showed amelioration of both epithelial cell vacuolisation and basal membrane deterioration. Numbers of hypoxia-inducible factor 1-immunostained Sertoli and Leydig cells were significantly higher in the hypoxia group than in the erdosteine group. The number of seminiferous tubules with caspase-3-immunostained germ cells was highest in the hypoxia group and decreased in the erdosteine and normoxia groups respectively. Based on these observations, erdosteine protects testis tissue from hypoxic injury by reducing apoptotic cell death.en_US
dc.identifier.doi10.1111/and.12041
dc.identifier.endpage58en_US
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue1en_US
dc.identifier.pmid23157213en_US
dc.identifier.scopus2-s2.0-84892459483en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://doi.org/10.1111/and.12041
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7984
dc.identifier.volume46en_US
dc.identifier.wosWOS:000330777900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUzun, Özge
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaspase 3en_US
dc.subjectErdosteineen_US
dc.subjectHIF-1 alphaen_US
dc.subjectHypoxiaen_US
dc.subjectTestisen_US
dc.titleErdosteine protects rat testis tissue from hypoxic injury by reducing apoptotic cell deathen_US
dc.typeArticleen_US

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