Serum omentin levels predicts mesenteric ischemia

dc.authorid0000-0002-3156-1076en_US
dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0002-7475-7298
dc.authorid0000-0002-4552-0048
dc.contributor.authorŞit, Mustafa
dc.contributor.authorAktaş, Gülali
dc.contributor.authorYılmaz, Edip Erdal
dc.contributor.authorTosun, Mehmet
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorAlçelik, Aytekin
dc.date.accessioned2021-06-23T19:42:34Z
dc.date.available2021-06-23T19:42:34Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground:Acute mesenteric ischemia (AMI) is an intestinal vascular disease with high mortality. Clinical diagnosis of acute mesenteric ischemia is difficult. Adipose tissue is an important mediator of metabolism and inflammation.Omentin is produced by visceral adipose tissue and decreased serum levels of omentin are associated with poor metabolic outcomes. We aimed to investigate whether serum omentin level predicts early diagnosis of AMI before development of transmural ischemia. Methods: Twenty-four Sprague Dawley rats weighted about 200-250 gr grouped in 3 experimental groups as sham, transient ischemia and permanent ischemia. Each group consisted of 8 rats. Blood samples were evaluated to determine serum urea, creatinine, omentin and C-reactive protein (CRP) levels. A blinded histological examination performed with the same histologist for hemotoxileneosine painted ileal tissue samples. Results: Mean serum omentin level in sham group (27.5+/-4.67) was significantly elevated compared to rats in Ischemia-reperfusion (IR) group (10.9+/-9.01).The difference reached the statistical significance (p=0.004). Serum omentin levels were not correlated to urea, creatinine or CRPlevels. Conclusion:Omentin levels may be a biochemical indicator to detect AMI. However, further human studies are needed (Tab. 3, Fig. 3, Ref 34).en_US
dc.identifier.doi10.4149/BLL_2015_035
dc.identifier.endpage176en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue3en_US
dc.identifier.pmid25869566en_US
dc.identifier.scopus2-s2.0-84928728392en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_035
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8534
dc.identifier.volume116en_US
dc.identifier.wosWOS:000351248700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞit, Mustafa
dc.institutionauthorAktaş, Gülali
dc.institutionauthorYılmaz, Edip Erdal
dc.institutionauthorTosun, Mehmet
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorAlçelik, Aytekin
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMesenteric Ischemiaen_US
dc.subjectOmentinen_US
dc.subjectEarly Diagnosisen_US
dc.subjectInflammationen_US
dc.subjectAdipose Tissueen_US
dc.titleSerum omentin levels predicts mesenteric ischemiaen_US
dc.typeArticleen_US

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