Intravenous Thrombolytic Therapy for Acute Ischemic Stroke:Experiences of a Tertiary Hospital in Turkey

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dc.contributor.authorYilmaz, Murat
dc.contributor.authorTeker, Handan
dc.contributor.authorYener, Merve Önerli
dc.contributor.authorGültekin, Edip
dc.contributor.authorÖgün, Muhammed Nur
dc.date.accessioned2024-09-25T20:17:08Z
dc.date.available2024-09-25T20:17:08Z
dc.date.issued2021
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to retrospectively collect the data of 95 patients with ischemic stroke who received intravenous (IV) tissue plasminogen activator (tPA) therapy between 2015 and 2019 in our clinic, to present the experiences of our clinic. Method: The data of the patients, who applied to our clinic with the diagnosis of acute ischemic stroke between 2015 and 2019, who received thrombolytic therapy, were reviewed retrospectively. General socio-demographic data, clinical features, National Institute Health Scale Scores (NIHSS), Alberta Stroke Program Early Computed Tomography (ASPECT) scores, symptom-to-door, door-to-needle, and symptom-to-needle times, treatment-related complications and Modified Rankin Scores (mRS) at the third month after treatment were evaluated.Results: Procedure-related major or minor bleeding complications developed in 18% of our patients who received tPA therapy. The mortality rate was 15% and 6.3% of these were caused by cerebral hemorrhage due to treatment complications and 8.7% were due to other systemic complications. Logistic regression analysis revealed that only the ASPECT score from factors that we found to be effective on the risk of developing complications was a highly effective factor in the development of complications (p=0.034, OR: 2.131). Conclusions: This study has shown that our results are generally compatible with the literature. Although there is an increase in the number of patients receiving tPA in our clinic every year, we aim to increase awareness of this therapy clinically and to expand the use of IV thrombolytic therapy in selected patients.en_US
dc.identifier.doi10.5798/dicletip.887410
dc.identifier.endpage64en_US
dc.identifier.issn1300-2945
dc.identifier.issn1308-9889
dc.identifier.issue1en_US
dc.identifier.startpage55en_US
dc.identifier.trdizinid409589en_US
dc.identifier.urihttps://doi.org/10.5798/dicletip.887410
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/409589
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15452
dc.identifier.volume48en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofDicle Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleIntravenous Thrombolytic Therapy for Acute Ischemic Stroke:Experiences of a Tertiary Hospital in Turkeyen_US
dc.typeArticleen_US

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