Botulinum toxin monotherapy for the treatment of essential tremor: Life quality effect
Yükleniyor...
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: This study aims to evaluate the effectiveness of botulinum toxin
therapy, as a monotherapy, and its effect on quality of life in patients with
essential tremor (ET) who are resistant to medical treatment or cannot tol erate optimum drug doses in the population.
Method: This retrospective research was conducted between February
2019 and December 2019 with 15 adult patients (9 men and 6 women)
in the 50-to-70 age group, who had a definite diagnosis of ET as evaluated
by the same clinician. With the help of electroneuromyography, intramus cular onabotulinum toxin A (BoNT-A) injection was administered to the re lated muscles, not exceeding 100 U in total. Demographic characteristics
and duration of disease of all patients were recorded. The tremor severity
of patients before the injection, 1 month after the injection, and 3 months
after the injection was assessed by the Fahn-Tolosa-Marín Tremor Rating
Scale (FTM-TRS), applied by the same clinician during the face-to-face in terviews, in addition to the Questionnaire for Essential Tremor (QUEST),
which was filled out by participants.
Results: The first month and third month mean QUEST and FTM-TRS
scores were statistically lower than that before the procedure in patients
with ET after BoNT-A injection (P = 0.001, P = 0.001, P = 0.001, and
P = 0.001). In addition, the mean FTM-TRS and QUEST scores for the
first month after the procedure were significantly lower than the mean
FTM-TRS and QUEST scores for the third month (P = 0.005 and
P = 0.007).
Conclusion: We believe that our study is valuable because there is no re search on the effect of BoNT-A administration on ET treatment in the our
country population and because the effect of BoNT-A treatment on quality of
life in patients with ET was evaluated using the ET-specific QUEST scale.
Açıklama
Anahtar Kelimeler
Essential Tremor, Botulinum Toxin, Quality Of Life
Kaynak
Clinical Neuropharmacology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
44
Sayı
1
Künye
Demiryurek, B. E. (2021). Botulinum toxin monotherapy for the treatment of essential tremor: life quality effect. Clinical Neuropharmacology, 44(1), 1-4.
