Increased plasma thrombin-activatable fibrinolysis inhibitor levels in young obese women with polycystic ovary syndrome

dc.authorid0000-0002-5344-9739en_US
dc.authorid0000-0002-4060-3354en_US
dc.contributor.authorAdalı, Ertan
dc.contributor.authorYıldızhan, Recep
dc.contributor.authorKurdoğlu, Mertihan
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorKolusarı, Ali
dc.date.accessioned2021-06-23T19:26:56Z
dc.date.available2021-06-23T19:26:56Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: To evaluate carotid intima-media thickness and thrombin-activatable fibrinolysis inhibitor levels in young women with polycystic ovary syndrome (PCOS) and age-matched healthy controls, and to investigate their relationship with each other and with clinical, metabolic, and hormonal parameters. Design: Clinical study. Setting: University hospital. Patient(s): Fifty young women with PCOS (overweight or obese [n = 24] and nonobese [n = 26]) and 25 age-matched healthy controls. Intervention(s): History and physical examination, peripheral venous blood sampling, carotid ultrasonography. Main Outcome Measure(s): Plasma thrombin-activatable fibrinolysis inhibitor, serum FSH, LH, DHEAS, total T, E-2, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, insulin resistance defined by the homeostasis model assessment insulin resistance index, and carotid intima-media thickness. Result(s): Plasma thrombin-activatable fibrinolysis inhibitor levels in the overweight or obese PCOS group were significantly higher than those in the nonobese PCOS and control groups. Carotid intima-media thickness did not significantly differ between the groups. Obesity and insulin resistance were associated positively with plasma thrombin-activatable fibrinolysis inhibitor levels, but there was no association between carotid intima-media thickness and thrombin-activatable fibrinolysis inhibitor. Conclusion(s): Young overweight or obese women with PCOS have increased plasma thrombin-activatable fibrinolysis inhibitor levels. Impaired fibrinolysis may be responsible for the increased risk of cardiovascular diseases in women with PCOS. (Fertil Steril (R) 2010;94:666-72. (C) 2010 by American Society for Reproductive Medicine.)en_US
dc.identifier.doi10.1016/j.fertnstert.2009.03.037
dc.identifier.endpage672en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue2en_US
dc.identifier.pmid19368913en_US
dc.identifier.scopus2-s2.0-77953720441en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage666en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2009.03.037
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6692
dc.identifier.volume94en_US
dc.identifier.wosWOS:000279758800038en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility And Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.subjectThrombin-activatable Fibrinolysis Inhibitoren_US
dc.subjectCarotid Intima-media Thicknessen_US
dc.subjectCardiovascular Diseaseen_US
dc.titleIncreased plasma thrombin-activatable fibrinolysis inhibitor levels in young obese women with polycystic ovary syndromeen_US
dc.typeArticleen_US

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