Increased plasma thrombin-activatable fibrinolysis inhibitor levels in young obese women with polycystic ovary syndrome
dc.authorid | 0000-0002-5344-9739 | en_US |
dc.authorid | 0000-0002-4060-3354 | en_US |
dc.contributor.author | Adalı, Ertan | |
dc.contributor.author | Yıldızhan, Recep | |
dc.contributor.author | Kurdoğlu, Mertihan | |
dc.contributor.author | Buğdaycı, Güler | |
dc.contributor.author | Kolusarı, Ali | |
dc.date.accessioned | 2021-06-23T19:26:56Z | |
dc.date.available | 2021-06-23T19:26:56Z | |
dc.date.issued | 2010 | |
dc.department | BAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | en_US |
dc.description.abstract | Objective: To evaluate carotid intima-media thickness and thrombin-activatable fibrinolysis inhibitor levels in young women with polycystic ovary syndrome (PCOS) and age-matched healthy controls, and to investigate their relationship with each other and with clinical, metabolic, and hormonal parameters. Design: Clinical study. Setting: University hospital. Patient(s): Fifty young women with PCOS (overweight or obese [n = 24] and nonobese [n = 26]) and 25 age-matched healthy controls. Intervention(s): History and physical examination, peripheral venous blood sampling, carotid ultrasonography. Main Outcome Measure(s): Plasma thrombin-activatable fibrinolysis inhibitor, serum FSH, LH, DHEAS, total T, E-2, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, insulin resistance defined by the homeostasis model assessment insulin resistance index, and carotid intima-media thickness. Result(s): Plasma thrombin-activatable fibrinolysis inhibitor levels in the overweight or obese PCOS group were significantly higher than those in the nonobese PCOS and control groups. Carotid intima-media thickness did not significantly differ between the groups. Obesity and insulin resistance were associated positively with plasma thrombin-activatable fibrinolysis inhibitor levels, but there was no association between carotid intima-media thickness and thrombin-activatable fibrinolysis inhibitor. Conclusion(s): Young overweight or obese women with PCOS have increased plasma thrombin-activatable fibrinolysis inhibitor levels. Impaired fibrinolysis may be responsible for the increased risk of cardiovascular diseases in women with PCOS. (Fertil Steril (R) 2010;94:666-72. (C) 2010 by American Society for Reproductive Medicine.) | en_US |
dc.identifier.doi | 10.1016/j.fertnstert.2009.03.037 | |
dc.identifier.endpage | 672 | en_US |
dc.identifier.issn | 0015-0282 | |
dc.identifier.issn | 1556-5653 | |
dc.identifier.issue | 2 | en_US |
dc.identifier.pmid | 19368913 | en_US |
dc.identifier.scopus | 2-s2.0-77953720441 | en_US |
dc.identifier.scopusquality | Q1 | en_US |
dc.identifier.startpage | 666 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.fertnstert.2009.03.037 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12491/6692 | |
dc.identifier.volume | 94 | en_US |
dc.identifier.wos | WOS:000279758800038 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.institutionauthor | Buğdaycı, Güler | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.relation.ispartof | Fertility And Sterility | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Polycystic Ovary Syndrome | en_US |
dc.subject | Thrombin-activatable Fibrinolysis Inhibitor | en_US |
dc.subject | Carotid Intima-media Thickness | en_US |
dc.subject | Cardiovascular Disease | en_US |
dc.title | Increased plasma thrombin-activatable fibrinolysis inhibitor levels in young obese women with polycystic ovary syndrome | en_US |
dc.type | Article | en_US |
Dosyalar
Orijinal paket
1 - 1 / 1
Küçük Resim Yok
- İsim:
- ertan-adali.pdf
- Boyut:
- 142.69 KB
- Biçim:
- Adobe Portable Document Format
- Açıklama:
- Tam metin/Full text