The relationship between rehabilitation outcomes and extracellular thiol-disulphide and intracellular oxidized-reduced glutathione homeostasis in patients with subacute stroke

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dc.authorid0000-0003-1856-9513en_US
dc.authorid0000-0003-0434-3206en_US
dc.contributor.authorAlışık, Tuğba
dc.contributor.authorAlışık, Murat
dc.contributor.authorÇoğalgil, Şirzat
dc.date.accessioned2023-08-07T11:42:47Z
dc.date.available2023-08-07T11:42:47Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground & Objective: To evaluate the relationship between the clinical outcome of subacute stroke patients and extracellular thiol-disulphide (SH-SS) and intracellular oxidized-reduced glutathione (GSSG-GSH) homeostasis and the effect of the rehabilitation program on these homeostasis.Methods: In this prospective observational study, outcome assessments (National Institutes of Health Stroke Scale Scores (NIHSS), modified Rankin Scale (mRS), and Barthel Daily Living Activities Index (BI)) and SH-SS and GSSG-GSH homeostasis parameters were investigated from 42 patients with subacute stroke before and after 4-week rehabilitation treatment protocol. Also, SH-SS and GSSG-GSH homeostasis parameters were measured from 35 healthy volunteers.Results: SS/SH and GSSG/GSH ratios were significantly higher in the patient group at baseline and post-rehabilitation than the control group (p<0.05). SS/SH ratio, GSSG/GSH ratio, NIHSS and mRS values significantly decreased with the rehabilitation (p<0.05). The baseline SS/SH and GSSG/GSH ratios were correlated with baseline and post-rehabilitation NIHSS, mRS and BI scores (p<0.05).Conclusions: The better outcomes of patients with higher baseline antioxidant thiol groups suggest that active thiol groups may play a role in achieving better outcomes in subacute stroke. In addition, rehabilitation treatment increased clinical scores and additionally shifted intracellular and extracellular thiol groups to the antioxidant side.en_US
dc.identifier.citationAlisik, T., Alisik, M., & Cogalgil, S. (2023). The relationship between rehabilitation outcomes and extracellular thiol-disulphide and intracellular oxidized-reduced glutathione homeostasis in patients with subacute stroke. Neurology Asia, 28(1).en_US
dc.identifier.doi10.54029/2023rye
dc.identifier.endpage129en_US
dc.identifier.issn1823-6138
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85153504860en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage121en_US
dc.identifier.urihttp://dx.doi.org/10.54029/2023rye
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11447
dc.identifier.volume28en_US
dc.identifier.wosWOS:000960957000014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAlışık, Murat
dc.institutionauthorÇoğalgil, Şirzat
dc.language.isoenen_US
dc.publisherAsean Neurological Assocen_US
dc.relation.ispartofNeurology Asiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThiolen_US
dc.subjectDisulfideen_US
dc.subjectGlutathioneen_US
dc.subjectStrokeen_US
dc.subjectStroke Rehabilitationen_US
dc.subjectOxidative Stressen_US
dc.titleThe relationship between rehabilitation outcomes and extracellular thiol-disulphide and intracellular oxidized-reduced glutathione homeostasis in patients with subacute strokeen_US
dc.typeArticleen_US

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