Çocuk yaş grubunda servis ve poliklinik kökenli üropatojen gram negatif çomakların antibiyotik duyarlılıkları
Küçük Resim Yok
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Çocuk Hastalıkları polikliniğinden ve servisinden gönderilen idrarlardan $10^5$ cfu/ml üzerinde sayıda izole edilen 205 Gram negatif çomak suşunun API 20E (bioMerieux) kiti ile identifikasyonları yapılmış, NCCLS M2-A6 kriterlerine göre Kirby-Bauer disk difüzyon yöntemi ile antibiyotiklere duyarlılıkları belirlenmiştir. Poliklinik hastalarından izole edilen 120 suşun 82’si E.coli, 23’ü Proteus spp., 10’u Klebsiella spp., 5’i Enterobacter spp. olarak; servis hastalarından izole edilen 85 suşun 49’u E.coli, 13’ü Klebsiella spp., 7’si Serratia spp., 5’i Pseudomonas spp., 4’eri Proteus ve Enterobacter spp., 2’si M.morganii, 1’i Citrobacter spp. olarak tanımlanmıştır. Poliklinik ve servis hastalarından izole edilen suşların duyarlılık oranları sırasıyla ampisiline % 5 ve % 7, amoksisilinklavulanik aside % 51 ve % 41, sefuroksime % 51 ve % 45, seftazidime % 77 ve % 53, imipeneme % 100 ve % 99, amikasine % 92 ve % 86, gentamisine % 79 ve % 68, siprofloksasine % 94 ve % 86, trimetoprim-sulfametoksazole % 31 ve % 41 olarak bulunmuştur. Sonuç olarak, çocuk yaş grubunda idrar yolu infeksiyonu etkeni olarak en sık E. coli saptanmıştır. Poliklinik suşları genellikle daha duyarlı olmakla birlikte, seftazidim dışında diğer antibiyotiklere poliklinikten ve servisten izole edilen suşların duyarlılıklarında anlamlı fark bulunmamıştır. Bu sonuçlar, poliklinik izolatlarında birçok antibiyotik için direnç oranlarının servis izolatlarına yaklaştığını düşündürmektedir.
From urine samples sent from pediatric policlinic and wards, 205 Gram negative rods were isolated as higher counts than $10^5$ cfm/ml. API 20E (bioMerieux) was used for identifications and the susceptibility tests were performed by Kirby- Bauer disk susceptibility method as recommended by NCCLS M2-A6. Hundred and twenty strains were isolated from outpatients and 82 of them were identified as Ecoli, 23 as Proteus spp., 10 as Klebsiella spp. and 5 as Enterobacter spp. Eighty-five strains were isolated from inpatients and 49 of them were identified as E.coli, 13 as Klebsiella spp., 7 as Serratia spp., 5 as Pseudomonas spp., 4 as Proteus spp., 4 as Enterobacter spp., 2 as M.morganii, 1 as Citrobacter spp. Susceptibility rates of isolates from outpatients and inpatients were respectively as follows: for ampicillin 5 % and 7 %; for amoxicillin-clavulanic acid 51 % and 41 %; for cefuroxime 51 % and 45 %; for ceftazidime 77 % and 53 %; for imipenem 100 % and 99 %; for amikacin 92 % and 86 %; for gentamicin 79 % and 68 %; for ciprofloxacin 94 % and 86 %; for trimethoprim-sulfamethoxazole 31 % and 41 %. In conclusion, E.coli was found as the most frequently isolated Gram negative rod from urinary tract infections in pediatric group. Although community acquired isolates were generally found more susceptible to antimicrobial agents, there was no statistically significant differences between susceptibility of the isolates from inpatients and outpatients except for ceftazidime. These findings suggest that resistance rates of outpatients’ isolates have been getting similar to inpatients’ isolates in children group.
From urine samples sent from pediatric policlinic and wards, 205 Gram negative rods were isolated as higher counts than $10^5$ cfm/ml. API 20E (bioMerieux) was used for identifications and the susceptibility tests were performed by Kirby- Bauer disk susceptibility method as recommended by NCCLS M2-A6. Hundred and twenty strains were isolated from outpatients and 82 of them were identified as Ecoli, 23 as Proteus spp., 10 as Klebsiella spp. and 5 as Enterobacter spp. Eighty-five strains were isolated from inpatients and 49 of them were identified as E.coli, 13 as Klebsiella spp., 7 as Serratia spp., 5 as Pseudomonas spp., 4 as Proteus spp., 4 as Enterobacter spp., 2 as M.morganii, 1 as Citrobacter spp. Susceptibility rates of isolates from outpatients and inpatients were respectively as follows: for ampicillin 5 % and 7 %; for amoxicillin-clavulanic acid 51 % and 41 %; for cefuroxime 51 % and 45 %; for ceftazidime 77 % and 53 %; for imipenem 100 % and 99 %; for amikacin 92 % and 86 %; for gentamicin 79 % and 68 %; for ciprofloxacin 94 % and 86 %; for trimethoprim-sulfamethoxazole 31 % and 41 %. In conclusion, E.coli was found as the most frequently isolated Gram negative rod from urinary tract infections in pediatric group. Although community acquired isolates were generally found more susceptible to antimicrobial agents, there was no statistically significant differences between susceptibility of the isolates from inpatients and outpatients except for ceftazidime. These findings suggest that resistance rates of outpatients’ isolates have been getting similar to inpatients’ isolates in children group.
Açıklama
Anahtar Kelimeler
Biyoteknoloji ve Uygulamalı Mikrobiyoloji, Tıbbi Laboratuar Teknolojisi, Mikrobiyoloji, Farmakoloji ve Eczacılık
Kaynak
ANKEM Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
18
Sayı
2
