Does serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?

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dc.contributor.authorÇekici, Yusuf
dc.contributor.authorSincer, Isa
dc.contributor.authorKaplangoray, Mustafa
dc.contributor.authorYilmaz, Mücahid
dc.contributor.authorYildirim, Arafat
dc.date.accessioned2024-09-25T20:16:49Z
dc.date.available2024-09-25T20:16:49Z
dc.date.issued2020
dc.departmentAbant İzzet Baysal Üniversitesien_US
dc.description.abstractAim: Several studies have found a correlation between coronary slow flow (CSF) and low serum high-density lipoprotein cholesterol (HDL-C) levels or high serum uric acid levels. The present study aimed to evaluate whether serum uric acid to HDL-C ratio predicts CSF.Material and Methods: The experimental (CSF) group included 91 patients (40 females, 51 males, mean age: 52±9) who had angiographically normal coronary arteries but had slow flow in one or more coronary arteries. The control group included 96 patients (57 females, 39 males, mean age: 50±9) with normal coronary anatomy and without slow flow. The uric acid to HDL-C ratio was calculated for the two groups and compared.Results: The HDL-C levels of the CSF group (37±8 mg/dL) were significantly lower compared to the controls (49±10 mg/dL, p<0.001), whereas serum uric acid levels (5.33±0.97 mg/dL) and uric acid to HDL-C ratio (0.14±0.03) of the CSF group were significantly higher compared to the controls (4.37±0.88 mg/dL and 0.09±0.02, p<0.001 and p<0.01, respectively).The receiver operating curve (ROC) analysis revealed that a cut-off >4.64 mg/dL uric acidand >0.119 % uric acid to HDL-C ratio had a sensitivity of 81% and 85% and specificity of 76% and 80% for determination of CSF, respectively (AUC=0.850, 95% CI: 0.792 - 0.908 and AUC=0.890, 95% CI: 0.841 - 0.940,respectively).Spearman's correlation test has been performed and a significant positive correlation has been detected between the uric acid to HDL-C ratio and the mean thrombolysis in myocardial infarction (TIMI) frame count (r=0.62, p<0.001).Conclusion: In this study, higher uric acid to HDL-C ratio values of the CSF group was found compared to the control group. Furthermore, uric acid to HDL-C ratio performed better than serum uric acid levels in predicting CSF.en_US
dc.identifier.doi10.5455/annalsmedres.2020.05.547
dc.identifier.endpage2573en_US
dc.identifier.issn2636-7688
dc.identifier.issue10en_US
dc.identifier.startpage2568en_US
dc.identifier.trdizinid414073en_US
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2020.05.547
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/414073
dc.identifier.urihttps://hdl.handle.net/20.500.12491/15229
dc.identifier.volume27en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzYK_20240925en_US
dc.titleDoes serum uric acid to high-density lipoprotein cholesterol ratio predict coronary slow flow?en_US
dc.typeArticleen_US

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