Prostaglandins E1 and E2 analogues ameliorate mucosal injury secondary to distal colonic obstruction
Yükleniyor...
Dosyalar
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor and Francis Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
After colonic obstruction, increased intraluminal pressure may impair blood circulation and cause mucosal injury that sometimes progresses to perforation. This experimental study aims to evaluated effects of prostaglandin E (PGE) analogues in order to prevent mucosal injury secondary to distal colonic obstruction. This study was carried out on 40 male Wistar rats equally divided into four groups: group 1, control; group 2, colonic obstruction by ligation of the sigmoid colon; group 3, obstruction and administration of PGE1; group 4, obstruction and administration of PGE 2. Mucosal structural changes were assessed and scored by histopathological examination at 24 h postoperatively. The thickness of the mucosal layer of the cecal wall was measured as 179.3 and 122 ?m (p < .001) in the control and obstruction alone group, respectively. Mucosal thickness was preserved by PGE1 (170 ?m) and PGE2 (157.3 ?m) administration. The mean damage score was 0.73 in the control and 3.3 (p < .001) in the obstruction alone group. This score was significantly lower in obstruction groups treated with both PGE1 and PGE2, 1.13 and 1.26 respectively (p < .001). Both PGE1 and PGE2 (PGE1 better than PGE2) ameliorate mucosal injury during distal colonic obstruction. We concluded that the administration of PGE analogues in case of mechanical obstruction of the left colon was beneficial for preserving the structure of the mucosal layer.
Açıklama
Anahtar Kelimeler
Colonic obstruction, Large bowel, Mucosal Injury, Prostaglandins
Kaynak
Journal of Investigative Surgery
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
16
Sayı
5
