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    Abelmoschus esculentus Seed Ethanol Extract Protects Against Lipopolysaccharide-Induced Lung Injury in Rats through Anti-Inflammatory Properties
    (Shaheed Beheshti University of Medical Sciences and Health Services, 2023) Tirink, Omer Faruk; Bekdas, Mervan; Cetinkaya, Ayhan; Duzcu, Selma Erdogan; Alısık, Murat; Yoldas, Meyri Arzu
    Background: Acute lung injury is respiratory failure due to various causes. Increased inflammatory and oxidative processes are recognized to play an essential role in the etiology of ARDS. Abelmoschus esculentus is an herbal product used to treat various diseases due to its anti-inflammatory and antioxidant effects. We aimed to investigate whether Abelmoschus esculentus has an effect on acute lung injury. Materials and Methods: In this experimental study, we used the ethanol extract of Abelmoschus esculentus seed. It divided forty male Wistar rats into five equal groups: 1) control, 2) Abelmoschus esculentus, 3) lipopolysaccharide, 4) lipopolysaccharide+Abelmoschus esculentus, and 5) lipopolysaccharide+ Abelmoschus esculentus +dexamethasone groups. Results: In the lipopolysaccharide group, native thiol, total thiol, IL-10, and IFN-? levels significantly changed. Abelmoschus esculentus was effective when used with dexamethasone in increasing native thiol and total thiol values (p=0.008 and p=0.004, respectively). On the other hand, when Abelmoschus esculentus was used alone, it significantly increased IL-10 levels and decreased IFN-? levels in the lipopolysaccharide group (p=0.025 and p<0.001, respectively). Additionally, improvements were noted in histological findings of alveolar congestion (p=0.006), intra-alveolar hemorrhage (p=0.006), and intra-alveolar macrophages (p=0.001). Conclusion: Abelmoschus esculentus, with its anti-inflammatory effect, may represent a new potential for treating acute lung injury. © 2023 NRITLD, National Research Institute of Tuberculosis and Lung Disease, Iran.
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    The relationship between blood biochemical parameters and oral health in children with obesity/overweight
    (Springernature, 2023) Yoldas, Meyri Arzu; Yilmazel, Simge Vural; Bolu, Semih; Danis, Aysegul
    Aim The purpose of this study was to evaluate the effects of obesity and overweight on the oral/dental health and blood biochemistry parameters in children.Methods A total of 87 children (29 boys, 58 girls) aged 1-18 presenting to our paediatric endocrinology outpatient clinic were included in the study. The patient group consisted of children with obesity/overweight and the control group consisted of children with normal weight. Paediatric patients were examined simultaneously by a paediatrician and a paediatric dentist. Oral/dental health examinations of all children included in the study were performed by a specialist paediatric dentist and dmft/DMFT (decayed, missing and filled teeth) values were calculated separately in the mixed dentition period. The Community Periodontal Index of Treatment Needs 23 index and the dental plaque 35 index were evaluated at oral/dental health examinations. Oral and dental health examination findings and blood biochemistry parameters were compared between the two groups.Results While DMFT, dental plaque index, blood c-reactive protein (CRP) and parathyroid hormone (PTH) levels were significantly increased in children with overweight/obesity compared to children with normal weight, there was no difference in terms of daily toothbrushing habits and last dental examination times. Overweight/obesity was found to be associated with the dental plaque and DMFT/dmft index, and elevation in the blood biochemistry parameters CRP and PTH among the children in this study.Conclusion The observation of significant elevation in DMFT and dental plaque indices and numbers of filled deciduous teeth showed that oral/dental health problems and dental decay may emerge more frequently in children with overweight/obesity. Children with overweight should be routinely provided with dental care as part of a multidisciplinary team that includes paediatricians and dentists. High c-reactive protein and parathyroid hormone values determined in children with obesity/overweight showed that excess weight causes an inflammatory process in the body.High, significant DMFT and dental plaque index scores detected in children with obesity/overweight may be evidence that overweight plays an effective role in dental caries in children.Excessive weight gain in children can cause oral and dental health problems, so necessary precautions should be taken.