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Öğe Astımlı çocuklarda büyüme ve puberte sürecinin değerlendirilmesi(Bolu Abant İzzet Baysal Üniversitesi, 2010) Yoldaş, Meyri Arzu; Uyan, Ayten PamukçuAstım; geri dönüşümlü diffüz alt havayolu obstruksiyonu ve bununsonucunda hipoksi oluşumu ile karakterize kronik bir hastalıktır. Ataklar sırasında,merkezi sinir sisteminin hipoksiye maruz kalması ve hipotalamo-hipofizer-gonadalaksın nörohormonal düzeninde bozukluk olması sonucu, astımlı çocuklarda büyümeve puberte süreci seyrinde seksüel maturasyonun etkilenebileceği ileri sürülmektedir.Ayrıca hastalığın klinik şiddeti, hastanın cinsiyeti, semptomların kontrol düzeyi veatak sıklığı, astımda kullanılan tedaviler de büyüme parametrelerini ve pubertegelişimini etkileyebilir. Bu çalışmada; astımlı çocuklarda, pubertal gelişimevrelerinin, benzer yaştaki sağlıklı çocuklarla karşılaştırılması ve istatistiksel olarakdeğerlendirilmesi amaçlanmıştır.Bu çalışma; Ocak 2007- Şubat 2010 tarihleri arasında, Abant İzzet BaysalÜniversitesi, İzzet Baysal Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalıve Çocuk Göğüs Hastalıkları Bilim Dalı polikliniğinde, astım tanısı ile takip edilen6-18 yaş arası hastaların, dosya kayıtları incelenerek retrospektif olarak yapılmıştır.Elde edilen verilerin istatistiksel analizi için SPSS 15.0 programı kullanılmış,istatistiksel analizlerde p<0.05 anlamlı olarak kabul edilmiştir.Çalışmaya 31'i erkek (%47,7), 34'ü kız (%52,3) toplam 65 hasta ve 27'sierkek (%49,1), 28'i kız (%50,9) olmak üzere 55 sağlıklı çocuk dahil edildi. Puberteevreleri kızlarda (telarş, pubarş, aksillarş, menarş) ve erkeklerde (genital gelişim,pubarş, aksillarş) ayrı ayrı Tanner sınıflamasına göre değerlendirildi. Çalışma grubuile kontrol grubu, kızlarda telarş başlama yaşı açısından karşılaştırıldığında, çalışmagrubunda telarş başlama yaşı kontrol grubuna göre istatistiksel olarak anlamlı düşükbulundu (p=0,015). Benzer şekilde çalışma ve kontrol grubunda erkekler, pubarşbaşlama yaşı açısından karşılaştırıldığında çalışma grubunda pubarş başlama yaşıkontrol grubuna göre istatistiksel olarak anlamlı düşük bulundu (p=0,023). Buçalışmanın sonucunda; astımlı çocuklarda puberte bulgularından, kızlarda telarşın,erkeklerde pubarşın sağlıklı çocuklara göre erken başladığı kanaatına varılmıştır.Anahtar Kelimeler: astım, büyüme, puberte süreci, çocukluk çağıÖğe The effect of Anatolian syrup on experimentally induced acetaminophen and lipopolysaccharide associated acute kidney injury(2022) Düzcü, Selma Erdoğan; Çetinkaya, Ayhan; Efe, Muhammet; Kayiş, Seyit Ali; Bekdaş, Mervan; Yoldaş, Meyri Arzu; Tirink, Omer FarukBackground: Acute kidney injury develops as a result of various etiologies and pathological mechanisms, with a high mortality rate. This study aimed to investigate the efficacy of Anatolian syrup on histopathological variables in experimentally induced acetaminophen and lipopolysaccharide associated acute kidney injury. Methods: In this study, 5 groups were formed using 40 male Wistar albino rats (200- 220g, 2-4 months old), as follows: Sham, acetaminophen (1 g/kg intraperitoneal (ip)), 3) lipopolysaccharide (5 mg/kg ip), acetaminophen (1 g/kg ip) + Anatolian syrup (15 days orally), and lipopolysaccharide (5 mg/kg ip) + Anatolian syrup (15 days orally).Tubular atrophy, tubular dilatation, cytoplasmic vacuolization in tubular epithelial cells, tubular epithelial cell necrosis, interstitial inflammation, congestion, hemorrhage, glomerular damage and loss of brushy border were evaluated histopathologically semiquantitatively using scoring from 0 to 5. Results: In histopathological variables, tubular atrophy, tubular dilatation, cytoplasmic vacuolization, necrosis, congestion, hemorrhage, glomerular damage, and loss of brushy border were significantly reduced in the acetaminophen + Anatolian syrup group compared to the acetaminophen group and in the lipopolysaccharide + Anatolian syrup group compared to the lipopolysaccharide group (p<0.001). Conclusions: The Anatolian syrup was shown to protect histopathological variables in kidney damage caused by acetaminophen and lipopolysaccharide.Öğe Effect of COVID-19 pandemic on children undergone percutaneous endoscopic gastrostomy due to neurologic diseases(2022) Bekdaş, Mervan; Daniş, Ayşegül; Kilinç, Yasemin Baranoğlu; Yoldaş, Meyri Arzu; Öztürk, HülyaAim: To investigate the effects of SAR-CoV-2 infection on nutritional status in patients who underwent \rpercutaneous endoscopic gastrostomy (PEG) for neurological disorders.\rMethods: The clinical and laboratory follow-up data of the patients who underwent PEG in our clinic between \r2002 and 2018 were evaluated before and during the pandemic. The results were analyzed statistically.\rResults: Twenty patients were included. They were 70.9±64.4 months old at the time of PEG, 97.9±67.8 \rmonths before the pandemic, and 105.5±60.8 months during the pandemic (p=0.048). Weight for age at the \rtime of PEG increased from 10.7±4.6 kg to 15.6±7.2 kg before the pandemic. Hemoglobin was 12.3±1.4 g/dl \rat the time of PEG, 13.5±1.6 g/dl before the pandemic (p=0.045). Vitamin D was 24.1±8.9 ng/ml at the time \rof PEG and increased to 45.7±9.7 ng/ml during the pandemic (p=0.018). The annual number of visits before \rthe pandemic was 9.8±5.7 and decreased to 2±1.7 during the pandemic (p=0.003). Twelve (%60) of the patients \rdeveloped PEG complications, 6(30%) had their PEG replaced. Those who had developed PEG complications \rhad low levels of albumin (3.3±0.4 vs 4±0.4 g/dl, p=0.022) and vitamin B12 (578±199 vs 1299±533 pg/ml, \rp=0.007). \rConclusions: Even if PEG is applied late, it provides a partial improvement in patients, but the COVID-19 \rpandemic reversed these benefits and caused an increase in PEG complications. In order for the patient to get \rthe maximum benefit from PEG, close follow-up is essential.Öğe The importance of inflammation markers in the diagnosis of COVID-19 in children(2022) Yoldaş, Meyri Arzu; Atasoy, Halil Ibrahim; Taş, Sinan; Dinçel, Gökçe Kaya; Dilek, MustafaAbstract Aim: To predict the presence of COVID-19 by readily available hematological and bio- chemical tests. Materials and Methods: A total of 58 children with signs indicative of COVID-19 (28 PCR positives for SARS-CoV2 and 30 negatives) were included in this retrospective study. Clinical and laboratory parameters have been compared between these groups. Results: White blood cell counts, RDW, MPV, NLR, PLR, LDH and CRP values were found to be higher in pediatric patients with positive PCR tests than children with negative PCR tests (p<0.05). There was a significantly positive correlation between CRP and NLR (r=.566, p<0.001), CRP and PLR (r=.462, p<0.001). Conclusion: CRP, NLR and PLR, which are frequently used as inflammation mark- ers, can help predict PCR positivity for SARS-CoV2. These easy-to-use tests can guide diagnosis in countries where access to PCR tests is limited.Öğe The importance of vitamins in pediatric COVID-19 patients(2022) Yoldaş, Meyri Arzu; Atasoy, Halil IbrahimIntroduction: This study aims to determine the effects of vitamin D (25-OH D), vitamin B12, and folic acid levels on the development and severity of the disease in pediatric COVID-19 patients. Methods: The files of 104 pediatric patients aged 0-17 years who applied to the pediatric service of our hospital with the suspicion of COVID-19 were reviewed retrospectively. Patients with positive PCR tests belong to the COVID-19 group (Group P), and patients with negative PCR tests were included in the control group (Group C). Patients diagnosed with COVID-19 were further divided into two groups: low vitamin D (Group I) and normal vitamin D (Group II). Results: The levels of vitamin D (25-OH D) and B12 were statistically significantly lower in the COVID-19 patient group (p<0.05). Discussion and Conclusion: We think that adequate vitamin B12 and vitamin D (25-OH) levels in children may be important in fighting against the COVID-19 infection.Öğe Multisystem inflammatory syndrome in children and shock: A case presentation(Springer, 2021) Tayfur, Aslı Çelebi; Bildik, Esra; Balcı, Paşa; Yoldaş, Meyri Arzu; Danış, AyşegülMultisystem inflammatory syndrome in children and shock: A case presentationÖğe A novel missense mutation in SLC12A3 gene in two siblings with Gitelman syndrome(Springer, 2022) Tayfur, Aslı Çelebi; Meral, Zehra; Yoldaş, Meyri ArzuTayfur, A. C., Meral, Z., & Yoldas, M. A. (2022, November). A NOVEL MISSENSE MUTATION IN SLC12A3 GENE IN TWO SIBLINGS WITH GITELMAN SYNDROME. In PEDIATRIC NEPHROLOGY (Vol. 37, No. 11, pp. 2943-2944).Öğe Pediatric COVID-19 disease: A review of the recent literature(Slack Inc, 2020) Yoldaş, Meyri Arzu; Yoldaş, HamitThe first pediatric coronavirus disease 2019 (COVID-19) case was confirmed in Shenzhen, China on January 20, 2020. At the beginning of the outbreak, COVID-19 pneumonia was more common in adults than in children and adolescents, and the rate of confirmed pediatric cases was relatively lower. However, as screening tests and pathogen detection campaigns were initiated in more regions as the outbreak spread, the number of pediatric infection cases increased significantly. Currently, studies on pediatric COVID-19 are limited in the literature to case reports and case series, and a few epidemiological studies. COVID-19 has distinct characteristics in the pediatric population compared to adults; therefore, we need to better understand the characteristics of this disease in children. Discovering the characteristics of the pediatric COVID-19 disease is important for contributing to the diagnosis and treatment of the disease in this population. In this review, clinical characteristics, epidemiology, diagnosis, and management of pediatric COVID-19 pneumonia based on the recent literature are discussed.Öğe The predictive role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyteratio in children with simple febrile seizures(2021) Yoldaş, Meyri Arzu; Hanci, Fatma; Dinçel, Gökçe Kaya; Bekdaş, MervanAim: To evaluate the predictive roles of biochemical and complete blood count parameters in the diagnosis of febrile seizures by comparing these between patients with simple febrile seizures and febrile patients without seizures. Methods: One hundred fifty-two children (66 girls and 86 boys), aged 6-60 months presenting with fever symptoms presenting to our hospital’s pediatric emergency department between January 2015 and January 2020 were included in the study. Demographic data, complete blood count parameters and biochemical parameter levels were compared between the two groups. These were divided into a patient group with simple febrile seizures (n = 74) and a febrile control group without seizures (n = 78). Results: Comparison of biochemical parameters revealed significantly higher glucose, CRP, and ALT levels in the febrile seizure group, while Ca and Na were significantly lower. Comparison of complete blood count parameters revealed significantly higher white blood cell (WBC), neutrophil, red cell distribution width, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) values in the febrile seizure group, while hemoglobin, hematocrit, mean corpuscular volume, lymphocytes, and mean platelet volume were significantly lower. Conclusions: We think that in addition to markers such as WBC, leukocytes, and CRP for evaluating inflammation in patients with febrile seizures, simple, easily available, and inexpensive tests such as NLR and PLR can also be useful for assessing inflammation.Öğe The Predictors of Pneumonia in Children with COVID-19(2023) Yoldaş, Meyri Arzu; Tayfur, Aslı Çelebi; Daniş, Ayşegül; Hanci, Fatma; Atasoy, Halil Ibrahim; Bolu, Semih; Cosgun, ZelihaThe purpose of this study was to evaluate the relationship between the presence of pneumonia and blood parameters in cases of Coronavirus disease (COVID-19) and to examine their predictive characteristics in terms of pneumonia. We reviewed the file records of 151 pediatric patients with a diagnosis of COVID-19 confirmed by the real time-reverse transcription polymerase chain reaction test in nasopharyngeal swabs. The patients were divided into two groups based on direct chest X-ray and computed tomography results in [Group 1 (n:41), with pneumonia findings, and Group 2 (n:110), with no pneumonia findings]. The groups’ demographic data, clinical and laboratory findings were compared. Pulmonary involvement was determined in 41 (27.1%) of the 151 patients. The [body mass index (BMI) Z-score], red blood cell distribution width (RDW), mean platelet volume (MPV), neutrophil lymphocyte ratio, passive leg raise, and D-dimer levels were significantly higher in patients with pneumonia than those without pneumonia in our study. Based on multivariate logistic regression analysis, BMI Z-score, MPV, and RDW were found to be independent risk factors of pneumonia in patients. The current study showed higher levels of blood parameters in patients with coronavirus disease 2019 (COVID -19) presenting with pneumonia than those without pneumonia. We suggest that BMI-Z score and MPV value may assist in predicting pulmonary involvement in patients with COVID-19.Öğe Protective and therapeutic effects of okra seed in acute nontraumatic brain injury(Taylor & Francis Ltd, 2023) Yoldaş, Meyri Arzu; Bekdaş, Mervan; Danış, Ayşegül; Çetinkaya, Ayhan; Düzcü, Selma Erdoğan; Alışık, Murat; Kocabey, Hüseyin; Türel, İdrisAimThe purpose of this study was to examine the protective and therapeutic effects of okra (Abelmoschus esculentus [AE]) seed extract, with its known antioxidant, immunomodulatory, and anti-inflammatory properties, in an acetaminophen (paracetamol, N-acetyl- para-aminophenol)-induced model of hepatotoxicity and subsequent acute non-traumatic brain damage.Material and MethodForty male Wistar rats were randomly divided into five equal groups, control, paracetamol (P), okra seed extract (AE), okra seed extract + paracetamol (P + AE), and okra seed extract + paracetamol + N-acetyl cysteine (NAC) (P + AE + N). AE was administered by oral gavage through a gastric tube at 600 mg/kg/day for seven days. On the eighth day of the procedure, a single 1 g/kg dose of paracetamol and 300 mg/kg NAC were injected via the intraperitoneal route 1.5 h after AE administration. Rat tissue specimens were subsequently subjected to biochemical and histopathological analyses. Levels of markers such as S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), and matrix membrane metalloproteinase-9 (MMP-9) were investigated from rat serum specimens. Malondialdehyde (MDA) and superoxide dismutase (SOD) were also measured to determine oxidant-antioxidant status.ResultsS100B, NSE, MMP-9, MDA levels, and SOD enzyme activities were examined using biochemical methods. MDA levels were significantly lower in the P + AE group and MMP-9 levels in the AE, P + AE, and P + AE + N groups compared to the P group. Histopathological examination results supported the biochemical findingsConclusionOkra seed extract exhibits a protective and therapeutic effect against non-traumatic brain damage resulting from acute paracetamol intoxication. We think that this benefit of AE derives from its antioxidant property.Öğe Similarities and differences between familial Mediterranean fever (FMF) and multisystem inflammatory syndrome (MIS-C) in children(2023) Yoldaş, Meyri Arzu; Tayfur, Aslı Çelebi; Hanci, Fatma; Daniş, Ayşegül; Bolu, Semih; Atasoy, Halil IbrahimAim: We aimed to reveal the similarities and differences between the rare and severe multisystem inflammatory syndrome (MIS-C) and active familial Mediterranean fever (FMF) disease in children. Our study may help in the early recognition of MIS-C syndrome in children and distinguish it from other diseases with similar symptoms. Methods: We evaluated the demographic and clinical characteristics, laboratory findings, treatments and outcomes of patients with MIS-C syndrome and active FMF. Results: The clinical and laboratory findings of a total of 66 patients hospitalized in our pediatric clinic with the diagnosis of active FMF (n:42) and MIS-C syndrome (n:24) were reviewed retrospectively. The reason for pediatric emergency admission was determined as resistant fever in all patients. When the clinical findings of the patients were compared, it was determined that joint and abdominal pain in the FMF group and vomiting, rash, cough, Lenfadenopati (LAP) and myalgia findings in the MIS-C group were statistically significantly higher (p<0.05). When the laboratory findings were evaluated between the two groups, the lymphocyte count and vitamin D levels were statistically significantly lower, while the leukocyte count, glucose, C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), sedimentation, aspartate aminotransferase (AST), alanine aminotransferase (ALT) were found to be significantly higher in the group with MIS-C syndrome (p<0.05 ). Conclusion: We think that the results of our study may guide pediatricians and clinicians in the early differential diagnosis and management of MIS-C, by showing the similarities and differences among MIS-C patients from autoinflammatory diseases such as FMF.
