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    Detection of cisplatin-induced ototoxicity with transient evoked otoacoustic emission test before pure tone audiometer
    (Springer, 2010) Yilmaz, Sueleyman; Oktem, Fatih; Karaman, Emin
    Our aim was to investigate cisplatin ototoxicity with transient evoked otoacoustic emission (TEOAE) test before it is seen with pure tone audiometer. In our study, we compared the hearing of the patients who are receiving 100 mg/m(2) 4-cycle cisplatin for lung cancer, with pure tone audiometer and transient evoked otoacoustic emission test in 1,000, 2,000 and 4,000 Hz. We found 55% hearing decrease with pure tone audiometer in patients that are receiving 100 mg/m(2) 4-cycle cisplatin for lung cancer. We also established emission amplitude decrease with TEOAE test in 85% of the patients. When we compare the patients' pure tone audiometer in 1,000, 2,000 and 4,000 Hz and TEOAE amplitude changes we did not find statistically significant results (P > 0.05), but when we compare the patients' TEOAE amplitude changes in 1,000, 2,000 and 4,000 Hz with control group we found statistically significant results (P < 0.05). Our results show that cisplatin ototoxicity could be find out with TEOAE test before it is seen with pure tone audiometer.
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    The effects of topical levobupivacaine on morbidity in pediatric tonsillectomy patients
    (Elsevier Ireland Ltd, 2009) Yilmaz, Sueleyman; Demiraran, Yavuz; Akkan, Nermin; Yaman, Hueseyin; Iskender, Abdulkadir; Guclu, Ender; Ozturk, Ozcan
    Objective: To reduce the post-tonsillectomy morbidity by swab soaked with 5 ml levobupivacaine hydroclorur (25 mg/10 ml). Study design: A double-blind prospective randomized controlled clinical study. Methods: In this randomized double-blind study in group I (30 children, mean age 7.5 +/- 2.6) we tightly packed swab soaked with 5 ml levobupivacaine hydroclorur (25 mg/10 ml) and in group II (21 children, mean age 7.9 +/- 3.7) we used 5 ml saline swabs into each of the two tonsillar fossae after tonsillectomy for 5 min. We used McGrath's face scale to compare the two groups in respect of pain control. Results: There was statistically significant pain relieving effect in the levobupivacaine group in the first 24 h (p < 0.05). But after 24 h pain relieving effect of levobupivacaine was not significant (p > 0.05). We did not see any serious complications for both groups. Postoperative morbidity mean results (nausea, vomiting, fever, bleeding, halitosis and ear pain) were not statistically different between the two groups (P > 0.05). Conclusion: Topical levobupivacaine seems to be a safe and easy medication for postoperative pain control in pediatric tonsillectomy patients. (c) 2009 Elsevier Ireland Ltd. All rights reserved.