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Öğe Bronchocentric granulomatosis with multifocal lung involvement: A case report(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2012) Kilicgun, Ali; Kurt, Bahar; Boluk, Murat; Yilmaz, FahriBronchocentric granulomatosis is a rare disease which shows no correlation between the clinical findings and radiological imaging. It is seen often in adults and is generally diagnosed by accident; however, a definitive diagnosis can be made with a lung biopsy. A necrotizing granulomatous reaction of the bronchi and bronchioles is generally observed. In this article, we present a 37-year-old male who was admitted for a detailed examination after a suspicious image was discovered on the chest X-ray. Many peripheral nodules were observed on computed tomography (CT) of the lung. Respiratory function tests revealed a mild obstruction, and a fiberoptic bronchoscopy showed no lesion. A nodule excision from the middle lobe in open lung biopsy was performed, and the result was found to be consistent with bronchocentric granulomatosis. We present this case due to its rare nature and believe it is a condition which should be investigated in terms of the etiology of multiple nodules.Öğe A case report of an Extraintestinal gist presenting as a giant Abdominopelvic tumor(2013) Çöl, Cavit; Yilmaz, Fahri[No abstract available]Öğe Differential expression of CD34, S100, and c-Kit in interstitial cells of Cajal in infantile hypertrophic pyloric stenosis - Immunochemical study(2009) Ozturk, Hulya; Ozturk, Hayrettin; Yilmaz, Fahri; Okur, Hanifi; Otcu, Selcuk; Dokucu, Ali IhsanBackground. The pathogenesis of infantile hypertrophic pyloric stenosis (IHPS) is poorly understood although many hypotheses have been proposed. Objectives. Assessment whether the differential expression of c-Kit, CD34, and S100 may be involved in the development of IHPS. Material and Methods. Specimens from 14 infants with IHPS and seven control subjects were immunohisto-chemically stained for c-Kit, CD34, and S 100. The numbers of CD34+, S 100+, and c-Kit+ cells in five random fields per specimen were compared via light microscopy (x200). Results. In normal pyloric tissue, specific and intense c-Kit immunoreactivity was observed in the muscle layers and moderate staining was observed around the myenteric plexus. In IHPS patients, c-Kit+ cells were either absent or markedly reduced around the myenteric plexus. In control and IHPS patients, CD34+ cells were not observed around the myenteric plexus. In the vascular endothelium, moderate CD34 staining was observed in specimens from control subjects, whereas intense staining was observed for IHPS patients. In normal pyloric tissue, moderate S 100 immunoreactivity was observed in the muscle layers and intense staining was observed in the myenteric plexus. In IHPS patients, few S100+ cells were observed in the pyloric muscle layers and S100 immunoreactivity decreased markedly around the myenteric plexus. Conclusions. These results suggest that the numbers of c-Kit+ and S100+ cells are markedly decreased in the pyloric muscle layers and around the myenteric plexus in IHPS patients. Thus a lack of c-Kit and S100, but not CD34, expression may be a critical factor in the pathogenesis of IHPS and may serve as a useful prognostic tool in the treatment of this disease. © Copyright by Wroclaw Medical University.Öğe The effect of ethyl cyanoacrylate on experimental posterior lateral spinal fusion in a rat model(Via Medica, 2009) Gezici, Ali Riza; Ergun, Ruchan; Yilmaz, Fahri; Gurel, KamilBackground and purpose: Cyanoacrylates (CAs) are a type of tissue adhesives which are currently the most commonly used for cutaneous closings. The use of CAs was reported in other clinical procedures such as odontology, neurological surgery, maxillary surgery, orthopaedics, plastic surgery, etc. In this experimental study the authors carried out posterolateral spinal fusion in a rat model to test the usefulness of ethyl-cyanoacrylate (ECA) in fixation of allograft/autograft fusions. Material and methods: 25 Sprague-Dawley rats were randomized into two study groups. Bilateral posterolateral lumbar intertransverse process spinal fusion was performed with both autograft and allograft in both groups. ECA gel was dropped in the fusion area In a rat model in group II. Results: The fusion rates as determined by manual palpation were 75% in controls and 46% in the ECA group (p = 0.322). According to radiographic score, the spinal segment was considered to be fused radiographically in 66% of controls and in 46% of animals in the ECA group (p = 0.43). The mean histological scores were 5.58 +/- 0.14 and 4.53 +/- 0.18 for the control and treatment group, respectively (p = 0.001). The mean bone density of the fusion masses was 101.3 +/- 2.5 in the control group and 92.0 +/- 3.3 in the ECA treatment group (p = 0.044). Conclusion: Ethyl-cyanoacrylate appeared to retard the osteogenic fusion but was well tolerated and did not induce necrosis, allergic reaction, infection, necrosis or neurological deficit in a rat model of posterolateral spinal fusion.Öğe Extralobar Pulmonary Sequestration in a Neonate(Aves, 2014) Ozturk, Hulya; Goksugur, Sevil Bilir; Dagistan, Emine; Yilmaz, Fahri; Ozturk, HayrettinCongenital pulmonary sequestration (CPS) is a type of thoracic malformation that may be represented as a solid or cystic mass composed of nonfunctioning primitive tissue. It does not interact with the tracheobronchial tree and has unusual systemic blood supply. Various congenital malformations may be presented with CPS. More than one-half of CPS cases are diagnosed in later childhood or even in adulthood. Neonates and infants are usually asymptomatic, and they are usually diagnosed due to the presence of other congenital anomalies. Here, we report a 5-day-old neonate who was admitted to our clinic with respiratory distress. CPS was diagnosed without any other malformation.Öğe Gorlin's Syndrome Presenting with Acrochordon Like Lesions(Deri Zuhrevi Hastaliklar Dernegi, 2010) Polat, Mualla; Atasoy, Halil Ibrahim; Senen, Dilek; Yildirim, Yasemin; Yilmaz, FahriNevoid basal cell carcinoma syndrome is a genodermatosis with autosomal dominant inheritance. Its clinical findings include multiple basal cell carcinomas, jaw cysts, pitting of the hands and feet, skeletal abnormalities, ectopic calcifications, and other less common abnormalities. We describe the development of pedunculated papules in a child with a clinical appearance of acrochordons that when removed showed basal cell carcinoma. These findings suggest that acrochordon in a child may be a sign leading to early diagnosis and deserve biopsy. (Turkderm 2010; 44: 96-8)Öğe Intussusception due to ınflammatory fibroid polyp located at ıleum: report of two cases(2007) Korkmaz, Özgür; Yilmaz, Hatice Gülşen; Yilmaz, FahriÖzet: İnflamatuar fibroid polip, gastrointestinal sistemin nadir görülen lezyonlarındandır. Sıklıkla mide ve ileumda rastlanır. Klinik semptomlar lezyonun yerleşim ve büyüklüğüne bağlıdır. İnce barsak yerleşimli inflamatuar fibroid polipler sıklıkla obstrüksiyon ve invajinasyon ile bulgu verirler. Bu çalışma ile ince barsak yerleşimli inflamatuar polibe bağlı ileoçekal ve ileoileal invajinasyon tespit edilen iki olgu sunuldu.Öğe Multiple eruptive dermatofibromas: Case report(2010) Hapa, Asli; Ersoy-Evans, Sibel; Yilmaz, Fahri; Erkin, GülDermatofibroma is a common, benign tumor of the dermis, often appearing as a solitary lesion of unknown etiology that presents on the lower extremities in adults. Multiple and eruptive dermatofibromas are unusual. Although the etiology of multiple eruptive dermatofibromas is unknown, most patients have underlying diseases of immune-mediated origin, such as autoimmune diseases, immunosuppressive treatments, HIV infection, and hematologic malignancies. Herein, we report an unusual case of multiple eruptive dermatofibromas that presented with nearly 100 well-circumscribed firm, tan to brown round papules (1-10 mm in diameter) all over the body, including the face, palms, and soles. The number of lesions increased gradually over a 2-year period, without any symptoms. Comprehensive clinical and laboratory diagnostic evaluation showed no evidence of an underlying disorder. Histopathological examination of one of the lesions from the patient's thigh revealed dermatofibroma. Based on these clinical and histopathological findings, the patient was diagnosed as a rare case of multiple eruptive dermatofibromas not associated with an underlying disease. Copyright © 2010 by Türkiye Klinikleri.Öğe Unilateral renal cystic diseasein a 15-year-old female: A left huge kidney associated with significant morbidity(2017) Öztürk, Hülya; Dağistan, Emine; Yilmaz, FahriUnilateral renal cystic disease (URCD) is a rare nonfamilial, nonprogressive disorder of one kidney and is not related with autosomal dominant polycystic kidney disease. The present case is a report of a 15-year-old female who had a huge multicystic mass involving the lower and middle part of the left kidney with normal minimal residual renal parenchyma at the upper pole. All the laboratory tests were within normal limits. The right kidney was entirely normal. Left nephrectomy was performed because of a significant morbidity. Here, the clinic, radiologic and pathologic findings are described and their differential diagnosis is discussed
