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Öğe Bilateral Thalamic Infarct: Occlusion of the Percheron Artery(Aves, 2013) Altunrende, S. Sevil; Canan, Arzu; Yildiz, Serpil; Yildiz, NebilÖğe Evaluation of autonomic nervous system dysfunction in fibromyalgia(2011) Şahin, Özlem; Yildiz, Serpil; Yildiz, Nebil; Yaşar, Mustafa Fatih; Kaptanoğlu, EceAmaç: Fibromyaljide (FM) otonom sinir sistemi (OSS) disfonksiyonu hakkındaki çalışmaların farklı sonuçları vardır. Bu çalışmadaki amacımız sempatik deri yanıtı (SDY) cevaplarını kullanarak FM hastalarında sempatik sinir sistemi disfonksiyonunu değerlendirmektir. Gereç ve Yöntem: Çalışmaya 27 fibromyaljili kadın hasta ve 18 sağlıklı gönüllü kadın kontrol alındı. FM hastaları ve sağlıklı kişiler Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE) ve FM için karakteristik olan kronik semptomlar yönünden sorgulandı. Sağ el palmar SDY, median sinirin bilek hizasında elektriksel olarak uyarılması ile elde edildi. Bulgular: FM hastalarında kronik semptomların çoğu yüksek orandaydı. Hastaların ve kontrollerin SDY amplitüd ve latansları arasında istatistiksel olarak anlamlı bir fark yoktu (p>0,05). BDE ve BAE ortalama değerlerine göre FM hastalarında anksiyete ve depresyon yoktu. Sonuç: Bu çalışmada FM’de OSS disfonksiyonu tesbit edilmedi. SDY sadece sudomotor aktiviteyi gösterdiği için OSS’nin tamamını değerlendirmede yetersiz bir yöntem olabilir. OSS disfonksiyonu FM’nin etyopatogenezinden ziyade FM’de gözlenen bazı kronik semptomlardan, eşlik eden depresyon ve anksiyeteden sorumlu olabilir. FM hastalarının kronik semptom, anksiyete ve depresyon durumları da gözönünde bulundurularak, OSS’nin alt sistemlerini (kardiyovasküler refleks yol, sempatik kolinerjik aktivite gibi) inceleyen çalışmalar ile OSS’nin FM etyopatogenezindeki rolünü belirlemek mümkün olabilir.Türk Fiz Tıp Rehab Derg 2011;57:62-5.Öğe The Evaluation of Small Nerve Fiber Dysfunction with Quantitative Sensory Testing in Patients with Type II Diabetes Mellitus without Large Fiber Neuropathy, and Normal Values for Thermal Thresholds(Aves, 2010) Yildiz, Nebil; Dogan, Nazile; Yildiz, Serpil; Altunrende, Burcu; Dikbas, OguzObjective: Quantitative sensory testing (QST) thermal threshold evaluation is used in order to determine small fiber neuropathy, and the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) Pain Scale is used in diagnosing neuropathic pain. The aim of this study is to find out the normal QST thermal threshold values, and to compare the QST values of normal controls and patients with type II diabetes mellitus, who do not have large fiber neuropathy. With this comparison, the study also aims to determine whether QST abnormalities are present in patients without neuropathic pain. Methods: A total of one hundred normal subjects between the ages of 20 and 69, and 50 patients with type II diabetes mellitus aged 40 to 69 years with no sign of large fiber neuropathy were recruited. The normal subjects were divided into 5 subgroups according to their ages. The mean values of the QST thermal detection and thermal pain thresholds were determined. Sixty normal subjects between the ages of 40-69 were defined as a control group for comparison with the diabetic group. The patients were divided into subgroups according to their LANSS points and their data were compared with the data of age-matched controls. Results: The mean ages of total normal subjects and the control group were 44.8 +/- 14.4 and 57.4 +/- 8.4, respectively. In diabetic group, according to LANSS, 10 patients (mean age, 55.1 +/- 8.5 years) scored above 12 (14.6 +/- 3.5), and 40 patients (mean age, 55.5 +/- 8.4 years) scored under 12 points (6.8 +/- 3.4). In the LANSS>12 group, the least abnormality rate was 100%, and the most frequently detected abnormality was in the foot cold pain threshold (70%). In the LANSS<12 group, the least abnormality rate was 67.5%, and the most frequently detected abnormality was in the hand cold pain threshold (45%). Conclusion: It was demonstrated that QST was successful in determining thermal detection abnormalities in all patients with probable neuropathic pain according to LANSS Pain Scale. QST is a test, which gives reliable and reproducible results in the diagnosis of small fiber sensory neuropathy. Because of its subjectivity and inefficacy in differentiation of peripheral and central causes, QST findings should be evaluated together with findings of neurological examination and nerve conduction studies. (Archives of Neuropsychiatry 2010;47:223-9)Öğe Multiple Sclerosis and Hashimoto's Thyroiditis: A Case Report(Aves, 2011) Altunrende, Burcu; Yildiz, Serpil; Yildiz, Nebil; Gurel, KamilIt has been suggested that multiple sclerosis (MS) is an immune-mediated disease directed against central nervous system (CNS) myelin, although the exact pathogenesis is still unclear. There are a lot of reports regarding the coincidence of MS with other immune-mediated diseases. In recent years, there have been only few case reports of MS associated with Hashimoto's thyroiditis. This coincidence is especially important from both clinical and therapeutic standpoints. In this case report, we present a patient with MS and Hashimoto's thyroiditis and summarize the clinical features. (Archives of Neuropsychiatry 2011; 48: 224-6)Öğe Relationship between intracellular pathogens Toxoplasma gondii and Borreliaburgdorferi infections and migraine(2021) Yilmaz, Murat; Yilmaz, Ayşen Tuğba Canbaşoğlu; Teker, Handan; Türkoğlu, Şule Aydin; Yildiz, SerpilAim: In this study, the serological values of our patients followed up with a diagnosis of migraine were compared with the results of healthy controls in terms of possible association with intracellular pathogens, Toxoplasma gondii and Borrelia burgdorferi. Methods: Fifty patients with migraine, randomly selected among migraine patients without any additional disease, who applied to Bolu Abant Izzet Baysal Training and Research Hospital between January 1, 2015 and August 31, 2019 were included in the study. Fifty subjects without headache were included as control group. The history of infectious diseases of the patient and control groups (Toxoplasma gondii, Borrelia burgdorferi- causing Lyme disease) was determined by serological diagnostic methods. Results: The study group consisted of 64 women with a mean age of 45.5±13.1 (15-76) years. Migraine and control groups were found to be similar in terms of age (p=0.059) and gender (p=0.211) distributions. The frequency of Toxoplasma gondii positivity in the migraine group was 28% (n=14) and 10% (n=5) in the control group. The frequency of Lyme was 19.6% (n=11) in the migraine group and 14.3% (n=8) in the control group. The frequency of Toxoplasma gondii positivity was statistically significantly higher in the migraine group (p=0.022), while the frequency of Lyme was found to be similar in the migraine and control groups (p=0.450). Conclusion: The results of our study suggest that there are statistically significant differences between migraine and control groups only in terms of Toxoplasma gondii positivity rates, not Lyme. However, we believe that larger sample studies are needed to determine the detailed relationship between migraine and Toxoplasma gondii infection.Öğe Sympathetic Skin Responses from the Neck Area in Patients with Unilateral Migraine(Aves, 2015) Korkmaz, Bektas; Yildiz, Serpil; Yildiz, NebilIntroduction: In this study, in patients with unilateral migraine headache and in normal controls, it was aimed to assess the sympathetic function during attack, post attack, and interval periods and to compare these findings by recording sympathetic skin responses from the neck area, which was not studied before. Methods: A total of 37 unilateral patients with migraine (30 women, seven men) who fulfilled the criteria of International Headache Society (2004) were recruited from our outpatient clinic. The control group consisted of 21 healthy individuals (16 women, five men) who are employees or students of our Medical Faculty. Mean latency and maximum amplitude values of sympathetic skin responses obtained from neck areas of the patients during attack, post attack, and interval periods were calculated. We compared the mean latency and the maximum amplitude values of the symptomatic side with the data of the asymptomatic side and with the data of the control group. We also compared the responses of the patients with right-sided headache with the responses of the patients with left-sided headache. All statistical analyses were performed using SPSS. Results: On the neck area, we observed sympathetic hypo-function in the attack and interval periods and a relative hyper-function in the post attack period bilaterally, regardless of the symptomatic side. Conclusion: These findings suggest that there is ongoing bilateral sympathetic hypo-function in the neck area and there occurs a temporary increase in the function of sympathetic sudomotor activity in the recovery period of headaches.
