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Öğe Atropa bellodonna fruit (Deadly Nightshade) related anticholinergic toxic syndrome: A case report(2013) Demirhan, Abdullah; Tekelio?lu, Ümit Yaşar; Yildiz, Isa; Korkmaz, Tanzer; Bilgi, Murat; Akkaya, Akcan; Koço?lu, HasanAtropa Belladonna related poisoning may lead to anticholinergic syndrome. Ingestion of high amounts of the plant may cause lethargy, coma, and even a serious clinical picture that could lead to death. In this case report, we aim to share a case of anticholinergic syndrome that developed after ingestion of the fruit called "Deadly Nightshade" in our country. © 2013 by Turkish Anaesthesiology and Intensive Care Society.Öğe Awake fibre-optic intubation in a patient with cervico-occipital fixator(2013) Akkaya, Akcan; Yildiz, Isa; Demirhan, Abdullah; Tekelio?lu, Ümit Yaşar; Koço?lu, HasanA 23-year-old male patient with cervico-occipital fixator was scheduled for surgery due to injuries to the right forearm. The patient's thyromental distance was 5 cm, mouth opening grade II, sternomental distance 10 cm and Mallampati score 4. The loss of extension of the neck in particular indicated difficult intubation. Anaesthetic procedures are almost always difficult in patients with cervico-occipital fixators; the limited cervical extension complicates both intubation and ventilation. In this report, application of general anaesthesia using awake fibre-optic bronchoscopic intubation (FOB) is described. After routine monitoring of vital signs and premedication, hypopharyngeal topical anaesthesia was applied with 10% lidocaine sprayed twice via the appropriate nostril. Superior laryngeal nerve block was performed with local anaesthetic infiltration of tissues 1 cm below the hyoid bone. Lingual and pharyngeal branches of the glossopharyngeal nerve were blocked. Transtracheal block was performed. Following completion of local anaesthesia, the patient, who was oxygenated with 5 L min-1 of 100% O2, was intubated using the awake FOB technique. After muscle relaxation, the patient underwent a microsurgical operation to repair eight tendons, one artery, and one nerve. Surgery lasted for 5 hours. When the extubation criteria were met, the patient was extubated. In cases of cervico-occipital fixation, which causes severe limitation of neck movements, the use of awake fibre-optic intubation should be considered. © 2013 by Turkish Anaesthesiology and Intensive Care Societ.Öğe Comparison of cerebral effects of thiopental and propofol infusion in traumatic brain injured rats(2022) Kiliccioğlu, Yıldıray; Yildiz, Isa; Yoldaş, Hamit; Karagoz, Ibrahim; Tekçe, Buket Kin; Çetinkaya, Ayhan; Bilgi, MuratObjective: Head trauma is a lethal, disabling, and pathological condition requiring long-term treatment and care. Thiopental and propofol infusions are frequently used for sedation in the intensive care unit (ICU). However, we do not have clear data on whether they are neuroprotective or neurotoxic. We aimed to compare the early cerebral effects of propofol and thiopental, which are used for sedation in acute head trauma. Methods: A total of 30 rats were included in this experimental study, and the animals were randomly divided into three groups; 5 ml/kg/h 0.9% dose NaCl infusion was given in the control group, 30 mg/kg/h dose propofol infusion was given in the propofol group, and 140 mcg/kg/h dose of thiopental infusion was given in the thiopental group. Blood samples were taken 4 hours after infusion. A craniotomy was performed, the brain was removed, and it was placed in 10% neutral formalin for histological examination. The materials were examined biochemically and histologically and then compared between the groups. Results: The S100B value between the groups was significantly lower in the thiopental group than in the control group (p=0.018). Tau protein levels were significantly lower in the propofol group than in the control group (p=0.07). In histological examinations, the number of apoptotic cells in the propofol and thiopental groups were significantly lower than in the control group (p=0.02). There was no significant difference between the propofol and thiopental groups in apoptotic cell numbers (p=0.3). Conclusion: Our study demonstrated that thiopental and propofol infusions following a head trauma reduced apoptotic cell death and caused a decrease in trauma markers.Öğe A Difficult Intensive Care Unit Monitorization Case: a Suicidal Attempt at 13 Years of Age by Hanging(2016) Yoldaş, Hamit; Soylemez, Esma; Karadayi, Husna; Erkuran, Mansur Kürşad; Bayir, Hakan; Yildiz, IsaZor bir yoğun bakım takibi: 13 yaşında ası ile özkıyım Özkıyım gün geçtikçe genç nüfus arasında artış gösteren global bir sorundur. Aile içi sorunlar, madde bağımlılığı, çocukluk depresyonlarındaki artış küçük yaşlarda ası gibi nadir yöntemlerin seçilmesine yol açabilmektedir. Küçük yaşlarda intihar oranının artması yoğun bakım takiplerine neden olabilmektedir. Psikososyal destek bu yaş gruplarında oldukça önemlidir. Bu sunumda onüç yaşında ası ile özkıyım girişimi sonrası yoğun bakımda takip edilen bir kız çocuğu tartışılacaktırÖğe Evaluating the efficiency of different propofol doses associated with age and gender in rats(2022) Yildiz, Isa; Yoldaş, Hamit; Çetinkaya, Ayhan; Çakmak, Mücahit; Çamsari, Çağrı; Ayaz, ErolAim: To investigate the effect of different intraperitoneal (IP) doses of propofol on the duration and depth of anesthesia according to age and gender. Method: The rats were divided into three main groups according to propofol dose (GI: 5 mg/kg, GII: 10 mg/kg and GIII: 15 mg/kg). These three groups were divided into two subgroups as male and female. (M: Male, F: Female). Male and female groups in each dose group were divided into five different sub-age groups: 1: 2-6 months (0-12 years = Childhood), 2: 7-12 months (12-18 years = Adolescent), 3: 13-18 months (30-45 years = Young adult), 4: 19-24 months (45-60 years = Adult) and 5: older than 25 months (65 years old = Elderly). The duration and depth of anesthesia in different ages and genders were compared statistically. Results: There were differences with regard to the palpebral, pinch, corneal and muscle tone reflexes at propofol administration doses of 5 mg/kg (GI), 10 mg/kg (GII) and 15 mg/kg (GIII) in different ages and genders (Table 1). We detected that 50 minutes of deep anesthesia was achieved with a dose of 10 mg/kg up to 18 months and older than 24 months male rats. A dose of 10 mg/kg was sufficient for short-term (20-minute deep anesthesia) procedures in male rats aged 19-24 months. We detected that 50 minutes of deep anesthesia was achieved with a dose of 15 mg/kg in 7-12 and 13-18 month old female rats. A dose of 10 mg/kg dose was sufficient for short-term procedures in 0-6 month old female rats. However, only superficial anesthesia was detected at the dose of 15 mg/kg in female rats older than 18 months. Conclusion: The present study demonstrated that 10 or 15 mg/kg low doses of intraperitoneal propofol administration affected the duration and depth of anesthesia in different ages and genders in rats.Öğe Evaluation of olfactory memory after sevoflurane anesthesia: Is really short-term memory influenced?(Scientific Publishers of India, 2016) Bayir, Hakan; Yildiz, Isa; Yoldas, Hamit; Karagöz, İbrahim; Kurt, Adem Deniz; Kocoglu, Hasan; Sereflican, MuratObjective: Olfactory disorders can negatively effect the quality of life. Few clinical studies and case reports have investigated the relationship between anesthesia and olfactory dysfunction. The aim of this study was to investigate the effect of sevoflurane on olfactory memory with Brief-Smell Identification Test™ in patients used sevoflurane. Patients and Methods: This, prospective, clinical study was performed on 60 ASA physical status I-II patients, between 18-65 years of age who were scheduled for expected surgery duration of 40-120 minutes. All patients were preoperatively informed about Brief-Smell Identification Test. For induction 2 mg.kg-1propofol, 0.5 mg.kg-1 rocuronium and 1 ?g.kg-1 iv fentanyl were administered. Anesthesia was maintained with the inhalational of anesthetic sevoflurane (2%). Brief-Smell Identification Test scores are recorded 30 minutes before the surgery and when the Aldrate Recovery Score reached 10 in the postoperative period. Preoperative and postoperative results were compared and p-values<0.05 were considered statistically significant. Results: The patients mean age were 47.1 ± 13.8. There was no statistically significant difference between the mean preoperative and intraoperative HR and MAP values. Preoperative total correct answer rate to odorous substances was 85.4%, and postoperative rate was 84.5%. Percentage of the odor identification by the patients revealed no statistically significant difference when pre and post-operative rates were compared (P>0.05). © 2016, Scientific Publishers of India. All rights reserved.Öğe Evaluation of the effect of intravenous ibuprofen use on postoperative pain and opioid consumption after abdominoplasty operation(2022) Türkoğlu, Mustafa; Yildiz, Isa; Gökkaya, Ali; Dişikirik, Akın; Demirhan, AbdullahAim: Abdominoplasty is a common cosmetic procedure that is one of the most painful aesthetic surgery and\rhas been used increasingly in recent years. Ibuprofen is a non-steroidal anti-inflammatory (NSAID) with\rantipyretic and analgesic effects. In this study, we aimed to evaluate the effectiveness of the intravenous (IV)\rform of ibuprofen on postoperative pain control and opioid requirement in patients who underwent\rabdominoplasty.\rMethods: The patients were divided into 3 groups as Group 1 (Tramadol), Group 2 (Ibuprofen) and Group 3\r(Tramadol HCL + Ibuprofen). Tramadol HCL was given continuous infusion at a concentration of 4mg / ml\rvia IV Patient Controlled Analgesia to Group 1. Ibuprofen 800 mg IV was administered to Group 2 at 30\rminutes before the end of the operation. Patients were followed up by administering 800 mg IV every 6 hours\rfor 24 hours. In Group 3, 30 minutes before the end of the operation, tramadol was administered via PCA with\rcontinuous infusion at a concentration of 4mg / ml and 800 mg IV ibuprofen was administered as 4x1.\rResults: VAS values were found to be significantly lower in Group 3 compared to Group 2 at every hour and\rat the 4th hour compared to Group 1. Group 3 was found to be significantly lower than Group 1 in total\ranalgesic consumption in all time zones.\rConclusion: We think that IV ibuprofen, which will be given in addition to tramadol after abdominoplasty,\rcan provide effective analgesia and reduce analgesic consumption.Öğe Neuroleptic malignant syndrome: A case report(2012) Tekelio?lu, Ümit Yaşar; Yildiz, Isa; Bayir, Hakan; Demirhan, Abdullah; Akkaya, Akcan; Duran, Arif; Koço?lu, HasanNeuroleptic Malignant Syndrome (NMS) is usually seen in patients who use antipsychotic drugs and has a high mortality rate. It is a life-threatening condition associated with dopaminergic blockage. Symptoms include high fever, diaphoresis, unstable blood pressure, unconsciousness, muscular rigidity, and autonomic dysfunction. The 46-year-old male patient who had a history of 10 years of klozapin use due to schizophrenia applied to the emergency service with unconscionsness, speech disorder and high fever. Having a history of irregular use of medicine in the recent past, the patient was restarted with klozapin as his symptoms increased. During the neurological examination, he had impaired consciousness and muscular rigidity. The laboratory analysis revealed the leukocyte 13.800/mm3, AST: 2.067 U/L, ALT: 295 U/L, LDH: 5.709 U/L, CK-MB: 1.189 U/L, CK: 123.889 U/L. He was diagnosed as NMS. By presenting this case, we aim to discuss the approaches to NMS and treatment modalities of NMS in light of the literature.Öğe Yoğun Bakım ünitesi Hastalarında Hepatit B, Hepatit C ve HıV Seroprevalansı(2015) Bayir, Hakan; Yildiz, Isa; Koçoğlu, Mücahide Esra; Kurt, Adem Deniz; Koçoğlu, HasanAmaç: Yoğun bakım ünitesi (YBÜ)çalışanları girişimsel işlemler, cerrahimüdahaleler, enjeksiyon gibi işlemleresnasında enfeksiyöz etkenlere maruziyetaçısından yüksek risk altındadır. Hepatit B(HBV), hepatit C (HCV) ve insan immünyetmezlik virüsü (human immunodeficiencyvirüs-HIV) en sık görülen etkenlerdir. Buçalışmada YBÜde yatan hastalarda HBsAg,anti-HCV ve anti-HIV seroprevalansınınaraştırılması amaçlanmıştır. Gereç ve Yöntem: Anesteziyoloji veReanimasyon YBÜde Ocak 2012-Aralık2014 tarihleri arasında yatan hastalarınkayıtları hasta dosyaları üzerinden HBsAg,anti-HCV ve anti-HIV açısından retrospektifolarak değerlendirildi. HBsAg, anti-HCV veanti-HIV testleri makroELISA yöntemiyle(Axsym-Abbott; Architect i2000-Abbott,ABD) çalışıldı. İstatistiksel değerlendirmeMann-Whitney U testi ve Ki-Kare testi ileyapıldı. Bulgular: YBÜye yatan 426 hastanınverilerine ulaşılabildi. Hastaların 169u(%39,7) kadın, 257si (%60,3) erkek idi.Hastaların dokuzunda (%2,1) HBsAg pozitifolarak bulundu ve hastaların hepsi erkekti.Anti-HCV pozitif 4 hasta (%0,9) tespit edildi.Bu hastaların da üçü erkek ve biri kadındı.Anti-HCV pozitifliği sadece bir kadın hastadarastlandı. Anti-HIV pozitifliğine rastlanmadı. Sonuç: Çalışmamızdaki HBV, HCV ve HIVsıklığı farklı branşlarda yapılan çalışmalardakisonuçlarla benzerlik göstermektedir vebenzer oranlarda bulaşma riski taşımaktadır.
