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    Assessment of quality of life and anxiety levels in patients who underwent electrophysiologic study due to unexplained palpitations
    (Turkish Soc Cardiology, 2013) Ozlu, Mehmet Fatih; Yildirim, Osman; Erdem, Alim; Ozturk, Serkan; Ayhan, Suzi Selim; Canan, Fatih; Yazici, Mehmet
    Objectives: To compare the quality of life and anxiety levels of the patients with normal and abnormal results detected during an electrophysiologic study (EPS) that was performed due to undocumented episodes of palpitations. Study design: The patients (n=128) with complaints of palpitations who underwent EPS because their arrhythmias could not be documented were included in the study. The quality of life and anxiety levels of patients with abnormal EPS results were compared to those with normal results using the 26-item short form of the World Health Organization quality of life scale and state-trait anxiety inventory. Results: SVT was found in 72 patients by diagnostic EPS. Quality of life scores were significantly poorer in the SVT group than those of the normal EPS group (p=0.0000.001). Likewise, the anxiety scores of the patients in the SVT group were higher than those of the group with normal EPS findings (p=0.000). Age, physical quality of life, psychological quality of life, state-and trait anxiety were found to be independent predictors of SVT in multivariate regression analysis. Conclusion: The level of anxiety was found to be higher and quality of life relatively lower in patients with palpitations due to SVT. In clinical practice during evaluation process of the patients with palpitations, it should be kept in mind that recognized psychiatric symptoms may be secondary to an underlying arrhythmia.
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    Atypical antipsychotic use is an independent predictor for the increased mean platelet volume in patients with schizophrenia: A preliminary study
    (2013) Semiz, Murat; Yücel, Hasan; Kavakçi, Önder; Yildirim, Osman; Zorlu, Ali; Yilmaz, Mehmet Birhan; Küçükdurmaz, Zekeriya
    Background: Cardiovascular diseases, cardiovascular risk factors, and mortality due to these situations are more frequently encountered in schizophrenic patients when compared with the general population. The mean platelet volume (MPV) is a surrogate biomarker of the platelet activity and an useful prognostic test in cardiometabolic diseases. The aim of this study was to investigate what influenced MPV levels in patients with schizophrenia. Materials and Methods: We evaluated hospital records of 60 hospitalized schizophrenia patients. Thirty age- and sex-matched healthy control subjects were also included as a control group. Results: MPV levels were significantly higher in patients who were on atypical antipsychotic drugs than in patients who were not using any drug (9.2 ± 0.8 vs. 8.6 ± 0.8 fL, P = 0.016) and also higher than control group (9.2 ± 0.8 vs. 8.1 ± 0.9 fL, P < 0.001). Furthermore, patients who were not using antipsychotics had higher MPV than control group (8.6 ± 0.8 vs. 8.1 ± 0.9 fL, P = 0.036). Atypical antipsychotic use [Odds ratio (OR) =6.152, 95% confidence interval (CI,) P = 0.003)] and platelet distribution width (OR = 0.989, 95% CI, P = 0.032) were associated with high MPV levels in univariate analysis. In multivariate logistic regression model, only atypical antipsychotics use (OR = 6.152, 95% CI, P = 0.003) was found to be independent predictor of high MPV levels after adjustment of other potential confounders (age, gender, presence of hypertension, diabetes mellitus, hyperlipidemia, and smoking). Conclusion: MPV seems to be influenced not only by schizophrenia itself but also by atypical antipsychotic drugs. It might be concluded that schizophrenic patients are under increased risk for cardiometabolic diseases and risk factors and this risk is higher in patients on atypical antipsychotic treatment.
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    A Preliminary Psychometric Evaluation of the Type D Personality Construct in Turkish Hemodialysis Patients
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2012) Alcelik, Aytekin; Yildirim, Osman; Canan, Fatih; Eroglu, Mustafa; Aktas, Glali; Savli, Haluk
    Objective: Type D personality, which is defined by both negative affectivity (NA) and social inhibition (SI), is associated with adverse outcomes in cardiac patients. The validity and reliability of the Type D Scale (DS_14) have been confirmed in various countries, particularly among cardiac patients. The purpose of the present study was to cross-validate the DS_14 in Turkish hemodialysis patients. Method: One hundred one patients, who had received maintenance hemodialysis for more than 3 months at a center in north-west region of Turkey, completed the Turkish version of the DS_14. Hospital Anxiety and Depression Scale (HAD) was administered to establish discriminant validity. The DS_14 was re-administered 1 month after first administration in order to examine the stability of the DS_14 in 100 patients. Results: The two-factor structure of the DS_14 and the internal consistency of the NA (alpha = 0.82) and SI (alpha = 0.81) subscales were confirmed. Both NA and SI were found to correlate positively with anxiety and depression scores. The DS_14 was stable over a 1-month period (r = 0.84/0.78; p< 0.01). The prevalence of Type D personality was 27.7%. Type D individuals had significantly higher mean scores on anxiety (p<0.01) and depression (p<0.01) subscales of the HAD when compared with non-Type D individuals. Conclusion: Preliminary evidence suggests that the Turkish DS_14 is a valid and reliable tool for identifying Type D personality. Future studies are warranted to evaluate the utility of the scale in different groups of patients.