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    Comparison of saline infusion sonohysterography and hysteroscopy findings in patients with abnormal uterine bleeding
    (2005) Alhan, Ali; Özdemir, Ismail; Somunkıran, Aslı; Demirci, Fuat; Yücel, Oǧuz; Bahçebaşi, Talat
    Objective: To establish the accuracy of saline infusion sonohysterography and hysteroscopy in diagnosing uterine pathology in women with abnormal uterine bleeding. Materials and Methods: A total of 39 women with abnormal uterine bleeding were recruited for the study and underwent transvaginal ultrasonography followed by saline infusion sonohysterography. During hysteroscopy, resection of the focal intracavitary lesion was performed. Endometrial sampling was obtained from all patients. Results: Sonohysterographic and hysteroscopic evaluation revealed 25 and 24 endometrial polyps, 7 each submucous myomas, 3 and 1 endometrial hyperplasia, 1 each synechia, and 3 and 6 normal findings, respectively. Comparison of histopathologic findings with other diagnostic tests revealed that hysteroscopy demonstrated a sensitivity of 97%, specificity of 72%, positive predictive value of 94%, negative predictive value of 83% and total sensitivity of 92%. Sonohysterography showed sensitivity of 97%, specificity of 29%, positive predictive value of 86%, negative predictive value of 85% and total sensitivity of 85%. Conclusion: In comparison with hysteroscopy, sonohysterography is a cheaper and easier procedure for detecting endometrial pathologies such as endometrial polyps and submucous myomas with its highly diagnostic value.
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    Two successive pregnancies after ursodeoxycholic acid therapy in a previously infertile woman with antimitochondrial antibody-negative primary biliary cirrhosis
    (Elsevier Inc., 2005) Korkut, Esin; Kısacık, Bünyamin; Akcan, Yusuf; Belenli, Olcay; Bicik, Zerrin; Yücel, Oǧuz
    Objective: To describe the benefit of ursodeoxycholic acid (UDCA) for the initiation and completion of a successful pregnancy in a previously infertile woman with primary biliary cirrhosis. Design: Case report. Setting: A university hospital with relevant departments. Patient(s): A 29-year-old woman with primary biliary cirrhosis and failure to conceive for 6 years. Intervention(s): Establishment of diagnosis with a liver biopsy, pretreatment of patient with UDCA before conception, and continuation of UDCA after first trimester until term. UDCA was used in the second pregnancy again after the first trimester. Main Outcome Measure(s): Achievement of a safe conception and full-term pregnancy. Result(s): Two consecutive successful pregnancies, a healthy 3,250-g male infant and a healthy 3,000-g female infant. The second conception occurred in a period without the use of UDCA, implicating a latent beneficial effect of either UDCA orthe previous pregnancy via some possible immune mechanism. Conclusion(s): Ursodeoxycholic acid could help achieve conception in infertile women with primary biliary cirrhosis. The use of UDCA after the first trimester is shown to be safe in two consecutive pregnancies. Although it cannot be conclusive, the unintentional use of UDCA in the first 20 days after conception did not result in any teratogenicity in the first child. © 2005 by American Society for Reproductive Medicine.