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Öğe Effects of specific inhibition of cyclooxygenease-2 on kidney in bilateral adrenalectomized rats(Springer, 2007) Öztürk, Hülya; Öztürk, Hayrettin; Gedik, Şenol; Uzunlar, Ali Kemal; Ketani, AydınIn the kidney, prostaglandins represent important physiological modulators of renal hemodynamics and salt and water homeostasis. In this experimental study of bilaterally adrenalectomized (ADX) rats, we aimed to investigate whether the administration of selective (celecoxib) inhibitor of COX-2 would alter the morphological and functional changes in rat kidney tissue. Twenty-one male Sprague-Dawley rats weighing 225-250 g were used. The animals were divided into three groups. Group 1 rats (Sham-control, n = 7) did not receive any treatment. In group 2 rats (ADX/Untreated, n = 7), bilateral ADX was performed via a single dorsal incision. In group 3 (ADX/COX-2) rats, the same operation was performed as described for group 2 and then the COX-2 inhibitor celecoxib was administered by gavage for a period of 7 days. On the 7th day of the study, renal function was assessed by measurements of blood urea nitrogen (BUN) and serum creatinine levels. Biopsies were obtained from the remaining left kidneys before killing the rats. There was no significant difference in the BUN and creatinine values between the groups. In ADX/Untreated group, capillary congestion in glomerule, inflammation, hemorrhage and congestion in intertubular area, and cytoplasmic vacuolation in renal tubules was observed. Mild damage was observed in the ADX/COX-2 group. The number of macrophages was significantly decreased in ADX/COX-2 group when compared to ADX/Untreated group (P < 0.0001). Our study indicates that celecoxib may be an important factor affecting renal morphological changes after the bilaterally ADX.Öğe Grading of the ovarian serous cystadencarcinomas, and its correlation with BRCA1 and p53 immunoreactivity(Ortadogu Ad Pres & Publ Co, 2007) Güneş, Nedim; Yılmaz, Fahri; Uzunlar, Ali KemalObjective: Ovarian cancer is a gynecological malignancy with the higest mortality. The surface epithelial tumors of the ovary are the most common cancer types. The purpose of this study was to grade the ovarian serous cystadenocarcinomas and to evaluate BRCA1 and p53 proteins immunohistochemically. Material and Methods: Fifty-eight cases diagnosed as serous cystadenocarcinomas of the ovary were selected for this study. The cases were graded according to two-tier grading system, FIGO and Shimizu-Silverberg grading system and the results were compared. The BRCA1 and p53 proteins were studied immunohistochemically. Results: The cases were distributed as follows: according to the two-tier grading system low grade 12 (21%) cases and high grade 46 (79%) cases; according to the FIGO grading system grade 19 (16%) cases, grade B 29 (50%) cases, and grade 11120 (34%) cases and according to the Shimizu-Silverberg grading system grade 111 (19%) cases, grade II 29 (50%) cases, and grade 11118 (31%) cases. Positive p53 staining was detected in 57% (33/58) and BRCA1 was detected in 67% (39/58) of the cases. The relationship between p53 and BRCA1 proteins and histopathologic grade was analyzed. High grade ovarian serous carcinomas had a higher rate of p53 expression (65%) compared to low grade (25%) tumors. BRCA1 immunstaining was detected in 92% (11/12) of low grade and 61% (28/46) of high grade tumors according to two-tier grading system. Conclusion: There is a good correlation between the two-tier grading system and the FIGO and the Shimizu-Silverberg grading systems. In addition, the application of the two-tier grading system for ovarian serous carcinomas is easy because this system is based on easily understood two criteria and includes two categories (low grade, high grade). In contrast to p53, high grade tumors had a lower rate of BRCA1 expression (61%) compared to low grade (92%) tumors. In high-grade carcinomas, no statistical correlation was present between the p53 and BRCA1 positivity (p= 0.666).Öğe Lentigo maligna and contiguous pigmented lesion(Deri Zuhrevi Hastaliklar Dernegi, 2013) Erdem, Hawa; Yildirim, Umran; Aliagaoglu, Cihangir; Turan, Hakan; Uzunlar, Ali KemalLentigo maligna (LM), a subtype of melanoma in-situ, is seen mostly in patients between 50 and 80 years old and accounts for ten to fifteen percent of skin cancer cases. LM is a traditional term for atypical pigmented macular lesions. LM occurs on severely sun damaged skin and it is usually on the face of elderly patients. Histological diagnosis of atypical pigmented macular lesions have extensive range from solar lentigo to in-situ melanoma (lentigo maligna pattern) or invasive invasive melanoma (lentigo maligna melanoma). The presence of solar lentigo, pigmented actinic keratosis, or reticulated seborrheic keratosis in incisional specimen could misguide the pathologist and clinician, they might think that lentigo maligna is not present. Therefore, excisional biopsy is needed in such cases. Our aim in presenting this case was to emphasize the importance of clinicopathologic correlation and to attract attention on the lesions adjacent to lentigo maligna which can lead to a misdiagnosis.Öğe LIFE-THREATENING ANGIOMYXOMA OF THE LARYNX(Jimma Univ, Ethiopia, 2015) Yaman, Huseyin; Erdem, Havva; Belada, Abdullah; Besir, Fahri Halit; Oktay, Murat; Uzunlar, Ali KemalBACKGROUND: Angiomyxoma is a benign proliferative mesenchymal tumor and a very rare mass in the larynx. There is not enough information about the etiology, clinical finding, treatment and prognosis of laryngeal angiomyxoma. CASE DETAILS: A 52 years old man presented with respiratory distress. Also, he had suffered from dysphagia, dysphonia, cough, and obstructive sleep apnea in the supine position for 6 months. He was operated on via transoral approach under general anesthesia with orotracheal intubation. The mass was encapsulated and completely removed. The histopathologic diagnosis was reported as angiomyxoma. CONCLUSION: Angiomyxoma should be considered in the differential diagnosis of the larynx masses. The treatment of angiomyxomas of the larynx is surgical. The mass can be usually excised intraorally or endoscopically.
