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Öğe The effect of the HMGB1/RAGE/TLR4/NF-?B signalling pathway in patients with idiopathic epilepsy and its relationship with toxoplasmosis(Wiley, 2024) Soyturk, Hayriye; Onal, Cansu; Kilic, Umit; Turkoglu, Sule Aydin; Ayaz, ErolThis study aims to investigate the relationship between toxoplasmosis and this pathway, which may be effective in the formation of epilepsy by acting through the HMGB1/RAGE/TLR4/NF-kappa B signalling pathway in patients with idiopathic epilepsy. In the study, four different experimental groups were formed by selecting Toxoplasma gondii IgG positive and negative patients with idiopathic epilepsy and healthy controls. Experimental groups were as follows: Group 1: Epilepsy+/Toxo- (E+, T-) (n = 10), Group 2: Epilepsy-/Toxo- (E-, T-) (n = 10), Group 3: Epilepsy-/Toxo+ (E-, T+) (n = 10), Group 4: Epilepsy+/Toxo+ (E+, T+) (n = 10). HMGB1, RAGE, TLR4, TLR1, TLR2, TLR3, IRAK1, IRAK2, IKBKB, IKBKG, BCL3, IL1 beta, IL10, 1 L8 and TNF alpha mRNA expression levels in the HMGB/RAGE/TLR4/NF-kappa B signalling pathway were determined by quantitative simultaneous PCR (qRT-PCR) after collecting blood samples from all patients in the groups. Statistical analysis was performed by one-way ANOVA followed by LSD post-hoc tests, and p < 0.05 was considered to denote statistical significance. The gene expression levels of HMGB1, TLR4, IL10, IL1B, IL8, and TLR2 were significantly higher in the G1 group than in the other groups (p < 0.05). In the G3 group, RAGE and BCL3 gene expression levels were significantly higher than in the other groups (p < 0.05). In the G4 group, however, IRAK2, IKBKB, and IKBKG gene expression levels were significantly higher than in the other groups (p < 0.05). HMGB1, TLR4, IRAK2, IKBKB, IL10, IL1B, IL1B, and IL8 in this signalling pathway are highly expressed in epilepsy patients in G1 and seizures occur with the stimulation of excitatory mechanisms by acting through this pathway. The signalling pathway in epilepsy may be activated by HMGB1, TLR4, and TLR2, which are considered to increase the level of proinflammatory cytokines. In T. gondii, this pathway is activated by RAGE and BCL3.Öğe Is increased activator protein 1 in cerebrospinal fluid as a potential biomarker that distinguishes idiopathic intracranial from sclerosis?(Aepress Sro, 2024) Karabork, Seyda; Celik, Humeyra; Dursun, Ali Dogan; Ankarali, Handan; Turkoglu, Sule AydinOBJECTIVES: To distinguish whether idiopathic intracranial hypertension (IIH) is a condition predisposing to multiple sclerosis (MS) or an isolated disease, the current gene transcription factor Activator Protein -1 (AP -1) was evaluated with its potential to differentiate both diseases. BACKGROUND: The aim of this study was to investigate the use of AP -1 as biomarkers for the discrimination of IIH and MS. METHODS: AP -1, TNF-alpha, and IL -6 protein values in the CSF of the cases were evaluated by the ELISA method. The numerical measures of the groups and the ability of AP -1 to distinguish the groups were analyzed with the ROC curve. RESULTS: There was no difference between the groups in CSF TNF-alpha, IL -6, CSF, and serum biochemistry analyses. However, it was determined that the AP -1 concentration (pg/ml) was significantly higher in the IIH group, the sensitivity of AP -1 in separating those with IIH was 75%, and the specificity in separating those with MS was 60% in those with an AP -1 concentration of 606.5 and above. CONCLUSION: According to our results, the fact that CSF TNF-alpha and IL -6 values did not differ in IIH compared to MS revealed that IIH could not methodologically control MS, and AP -1 was a supportive parameter in differentiating both diseases (Tab. 2, Fig. 1, Ref. 31) . Text in PDF www.elis.skÖğe Presynaptic Inhibition and Disynaptic Reciprocal 1a Inhibition in Parkinson's Disease, The Effect of The Dopaminergic Treatment(Journal Neurological Sciences, 2010) Yildiz, Nebil; Turkoglu, Sule Aydin; Yildiz, Serpil Kuyucu; Altunrende, BurcuObjective: In recent years, increasing number of studies about the spinal cord pathology in Parkinson's disease had been conducted. H reflex investigation is an important choice in the studies dealing with neurophysiological and interneuronal alterations of the spinal cord. The effect of the dopaminergic treatment on the spinal interneuronal reflex pathways is a relatively less investigated issue. This study has been adressed to assess the presynaptic and disynaptic inhibition levels in Parkinson's disease, and the effect of dopaminergic treatment. Methods: Presynaptic inhibition and dysynaptic reciprocal 1a inhibition is investigated by double stimulation of the tibial nerve at the popliteal fossa and peroneal nerve at the fibular head in patients with Parkinson's disease and also in control subjects for the 1-100 ms conditioning test intervals. The amplitude changes of the test and the conditioned H reflex responses were calculated and compared in the affected and less affected sides in both before and under dopaminergic treatment. Results: Disynaptic and presynaptic inhibitions existed in all subjects. Disynaptic reciprocal 1a inhibition was shortened only at 2 ms conditioning interval. The conditioned and test H reflex ratio (Hc/Ht) for the 20 ms conditioning test interval (presynaptic inhibition) was significantly smaller in the affected side than the controls (p: 0.046). The percentages of the inhibitions for the 20-10-5-3-2 ms conditioning intervals significantly increased in the affected side under treatment when compared with the ones obtained in the pretreatment period (p: 0.031, 0.027, 0.014, 0.026, 0.037). Conclusion: Presynaptic inhibition was decreased and disynaptic inhibition duration was shortened in the affected side of the patients with Parkinson's disease, dopaminergic treatment caused significant increases in both periods of inhibition. These findings indicate an abnormal supraspinal influence on the spinal cord in Parkinson's disease, and also the role of some dopa responsive neural mechanisms.Öğe Recurring disease activity in relapsing remitting multiple sclerosis: The multicenter RDA-RMS study(Elsevier Sci Ltd, 2024) Tunc, Abdulkadir; Yetkin, Mehmet Fatih; Seferoglu, Meral; Inanc, Yilmaz; Sivaci, Ali Ozhan; Turkoglu, Sule Aydin; Baydar, CanerBackground: This study investigates the gap in understanding the dynamics of recurring disease activity (RDA) in RRMS patients after fingolimod (FGL) treatment discontinuation. The aim is to investigate RDA in RRMS patients after stopping FGL, aiming to improve management and comprehension of disease progression post-treatment. Methods: In this multicenter, retrospective study, data from 172 of 944 RRMS patients aged 18-55, across nine centers in Turkey, who discontinued FGL treatment, were analyzed. The collected data included EDSS scores, annualized relapse rates (ARR), lymphocyte counts, and MRI findings, with follow-up assessments conducted at 6 months, 1 year, and up to 2 years. Results: RDA was observed in 31.9 % of patients, with incidences of rebound and reactivation at 20.3 % and 11.6 %, respectively. Factors like younger age, longer treatment duration, lower lymphocyte counts, and higher lesion burden increased RDA risk. Notably, 52.9 % of pregnant patients experienced RDA (16.4 % of the overall RDA group), with rebound occurring in six and reactivation in three. Patients with RDA had longer medication-free intervals and increased ARR. Discontinuation reasons varied, with disease progression linked to a lower RDA risk. Conclusion: Findings highlight the necessity for personalized management and vigilant monitoring after FGL discontinuation in RRMS patients, offering critical insights into RDA risk factors, and the complex interplay between treatment cessation, pregnancy, and disease progression.
