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    Depression in pregnancy is associated with decreased glutathione peroxidase activity in fetal cord blood
    (Pergamon-Elsevier Science Ltd, 2016) Camkurt, Mehmet Akif; Findikli, Ebru; Bakacak, Murat; Karaaslan, Mehmet Fatih; Tolun, Fatma Inanc; Tuman, Taha Can
    The investigation of fetal cord blood (FCB) during child delivery has created a novel topic in the field of psychiatric research. The umbilical vein receives nutrients and oxygen from the mother's circulation and transports them to the fetal circulation. Investigating fetal cord blood during delivery is beneficial for understanding the fetal environment. Depression in pregnancy is associated with medical and emotional burdens. In this study, we aimed to investigate glutathione peroxidase (Gpx) and myeloperoxidase (MPO) activity in the FCB of depressed mothers and healthy controls. Our study included 45 depressed mothers and 59 healthy controls. The FCB samples were collected from the umbilical vein during delivery. We found that Gpx levels were significantly decreased in the FCB of depressed mothers than healthy controls, medians were 0.14 U/ml and 0.16 respectively, Z: -3.567 and p < 0.001. MPO levels were similar in both groups, medians were 1.0 U/L and 1.2 U/L respectively, Z: -1.837 and p:0.066. Depression in pregnancy may be associated with decreased antioxidant levels, and this condition may cause an oxidative load, which may lead to improper brain development. Future studies should be performed in larger samples to clarify our preliminary results. (C) 2016 Elsevier Ltd. All rights reserved.
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    Effects of music therapy on pain and oxidative stress in oocyte pick?up: a randomized clinical trial
    (Elsevier Editora Ltda, 2020) Orak, Yavuz; Bakacak, Suleyman Murat; Yaylali, Asli; Tolun, Fatma Inanc; Kiran, Hakan; Boran, Omer Faruk; Kurt, Akif Hakan
    Background and objective: The aim was to investigate the effects of Turkish classical music on pain and oxidative stress in patients undergoing oocyte pick?up. Methods: The study was a randomized, controlled trial. The groups included were Group NM (Non?Music), control group; Group PM, which comprised patients who listened to music before the operation; and Group CM, which comprised patients who listened to music both before and during the operation. Blood was drawn prior to the operation to measure the oxidative stress values. Pain, hemodynamic parameters, oxidative stress values were assessed postoperatively. Results: The number of patients requiring additional propofol was higher in Group PM than in Groups NM and CM (p = 0.003). The postoperative Visual Analog Scale (VAS) score were lower in Groups PM and CM than in Group NM (p = 0.001, p = 0.007) in the 1st and 60th minutes. The postoperative VAS score was lower in Group CM than in Group NM (p = 0.045) in the 5th minute. The postoperative additional analgesic requirements were lower in Groups PM and CM than in Group NM (p = 0.045). The postoperative blood glutathione peroxidase values were significantly higher in Groups PM and CM than in Group NM (p = 0.001). The postoperative catalase values were significantly higher in Groups PM and CM than in Group NM (p = 0.008 and p ? 0.001). The preoperative malondialdehyde values were significantly lower in Groups PM and CM than in Group NM. The preoperative nitric oxide values were higher in Groups PM and CM than in Group NM (p ? 0.001), whereas the postoperative nitric oxide values were lower in Groups PM and CM than in Group NM (p ? 0.001). Conclusion: Turkish classical music has beneficial effects on pain and oxidative stress in oocyte pick?up patients. © 2020 Sociedade Brasileira de Anestesiologia