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    Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID-19, and radiotherapy
    (John Wiley and Sons Ltd, 2023) Taysi, Seyithan; Algburi, Firas Shawqi; Taysi, Muhammed Enes; Caglayan, Cuneyt
    Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti-cancer, anti-inflammatory, antioxidant, antibacterial and anti-fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS-CoV-2. This review covers in detail the importance of CAPE in alternative medicine, its pharmacological value, its potential as a cancer anti-proliferative agent, its dual role in radioprotection and radiosensitization, and its use against coronavirus disease 2019 (COVID-19). © 2022 John Wiley & Sons Ltd.
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    Dantrolene: In doxorubicin toxicity
    (2007) Büyükokuroğlu, Mehmet Emin; Taysi, Seyithan; Büyükavcı, Mustafa; Memişoğulları, Ramazan
    Doxorubicin (DOX) is a widely used anthracycline in the treatment of hematological and solid tumors. However, there are serious toxic effects on cardiovascular and hematopoietic system, which limits the use of the drug. This study examines the effect of dantrolene (5 and 10 mg kg-1) on DOX (20 mg kg-1, i.p.)-induced cardiotoxicity and hematotoxicity in normal rats. Change in nitric oxide (NO.) levels in cardiac tissue were measured and hemoglobin (Hb), white blood cells (WBC), red blood cells (RBC) and platelets were counted with an automatic counter. Pretreatment of rats with 5 and 10 mg kg-1 doses of dantrolene, markedly reduced the NO . levels in the cardiac tissue. The hematotoxicity was characterized by leukopenia and thrombocytopenia that appeared after 48 h of single dose DOX (20 mg kg-1) administration. Dantrolene (5 and 10 mg kg-1) 0.5 h before doxorubicin injection ameliorated the hematotoxicity induced by doxorubicin. These results showed that dantrolene has provided a protective effect against DOX-induced nitrosative stress in the heart and hematotoxicity.