Yazar "Sungur, Mehmet Ali" seçeneğine göre listele

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    Evaluating clonidine response in children and adolescents with attention-deficit/hyperactivity disorder
    (Amer Inst Mathematical Sciences-Aims, 2018) Kütük, Meryem Özlem; Güler, Gülen; Tufan, Ali Evren; Sungur, Mehmet Ali; Topal, Zehra; Kütük, Özgür
    Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood, which is generally treated with stimulant and non-stimulant medications. However, 10-30% of patients in clinical setting do not present with adequate response to initial stimulant treatment. Thereby, clonidine may be considered for those patients who have failed to respond to psychostimulant/atomoxetine monotherapy or as an augmentation for inadequate response/comorbidity. This observational study evaluated its effectiveness as a single drug in ADHD cases unresponsive to previous treatment trials. Seventeen ADHD cases that were non-responders to stimulant, non-stimulant and combination therapy for the primary symptoms of ADHD were included in the study. Four cases dropped out before follow up, leaving thirteen cases who were administered immediate release clonidine treatment alone with a mean dose of 0.2 +/- 0.05 mg/day at baseline. The trial lasted for 12 weeks, and treatment outcomes were evaluated by the Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale (T-DSM-IV-S) and the Clinical Global Impressions-Severity (CGI-S) and Improvement (CGI-I) scales. Mean age of the sample was 12.5 years (SD = 3.0) and eleven of the subjects had another comorbid psychopathology. Only two cases were evaluated as "very much improved", while another patient was judged to be "minimally improved" after 12 weeks of clonidine treatment. Attrition during follow-up was associated with higher median scores on the hyperactivity and impulsivity subscales (Mann-Whitney U test, p = 0.02). According to the T-DSM-IV-S, CGI-S, and CGI-I scales, clonidine treatment by itself had minimal benefits in this sample of treatment of refractory cases with ADHD evaluated at the study center. Clonidine is not available in Turkey pharmaceutical marketing system and patients' access to drug is limited. Our results provide first data regarding the use of clonidine in Turkish ADHD patients.
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    Evaluation of the effect of galanin and exercise on anxiety in rats by open field and elevated plus maze tests
    (Duzce University Medical School, 2018) Mermerci , Asuman; Özmerdivenli, Recep; Orallar, Hayriye; Beyazçiçek, Ersin; Sungur, Mehmet Ali
    Aim: Anxiety, known as worry, considered normal in everyday life, and also it is a type of behavior developed to protect the organism. The aim of this study is to investigate the effects of exogenous galanin given with exercise on anxiety. Material and Methods: In this study 96 adult male Wistar Albino rats were used. Rats were divided into 8 groups with twelve animals, and 4 of the groups were given regular exercise for 6 weeks. Galanin was administered intraperitoneally (IP) and intracerebroventricular (ICV) in half of the groups and saline was injected into the control group of each group with the same methods. At the end of the sixth week, open field and elevated plus maze tests were applied to the rats, and these tests recorded with the camera. The recordings of the both tests were analyzed, and total distance and speed values, the time spent in the open field test and the time spent in the closed arm of elevated plus maze were compared. Results: In the open field test were determined that in general, the total distance (p<0.001) and the speed increased (p<0.001) in rats injected with ICV compared to the rats injected with IP. There is no significant difference was detected in terms of exercise and galanin interaction. Also the total distance (p=0,032) and the speed increased (p=0,010) in rats injected with ICV compared to the rats injected with IP. In elevated plus maze test, exercise and galanin interaction were not found to be statistically significant, however the interaction between the injection pattern and the given substance was found to be significant in terms of time spent in the closed arm (p=0.020) and speed (p=0.032). Conclusion: Although it has been shown that central administration of galanin may have anxiolytic activity, this effect has not changed with exercise, and also it has been determined that exercise with galanin has no effect on this activity. © 2018, Duzce University Medical School. All rights reserved.
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    Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: One-pot synthesis, characterization, and anticancer and antibacterial activities
    (Beilstein-Institut, 2023) Kurt, Akif Hakan; Olutaş, Elif Berna; Avcıoğlu, Fatma; Karakuş, Hamza; Sungur, Mehmet Ali; Öztabağ, Cansu Kara; Yıldırım, Muhammet
    The presented study comprises the one-pot synthesis and the characterization of quercetin-and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles (Ch/Q-and Ch/CA-Ag NPs), and their antibacterial and anticancer activities. The formation of Ch/Q-and Ch/CA-Ag NPs has been confirmed by ultraviolet-visible (UV-vis) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM). The characteristic surface plasmon resonance (SPR) absorption band has been found at 417 and 424 nm for Ch/Q-and Ch/CA-Ag NPs, respectively. The formation of a chitosan shell comprising quercetin and caffeic acid, which surround the colloidal core Ag NPs, was confirmed by UV-vis, and FTIR analyses, and moni-tored by TEM microscopy. The size of nanoparticles has been determined as 11.2 and 10.3 nm for Ch/Q-and Ch/CA-Ag, respec-tively. The anticancer activity of Ch/Q-and Ch/CA-Ag NPs has been evaluated against U-118 MG (human glioblastoma) and ARPE-19 (human retinal pigment epithelium) cells. Both NPs showed anticancer activity, but Ch/Q-Ag NPs seemed to be more effective on cancer cell lines (U-118 MG) in comparison to healthy ones (ARPE-19). Furthermore, the antibacterial activity of Ch/Q-and Ch/CA-Ag NPs against Gram-negative (P. aeruginosa and E. coli) and Gram-positive (S. aureus and S. epidermidis) bacteria was determined, and dose-dependent antibacterial effects were found.