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    The effect of melatonin on tinnitus with respect to sleep and depression: A randomized clinical trial
    (2012) Koybasi, Serap; Boztas, M. Hamid; Bicer, Yusuf Ozgur; Serin, Erdinc; Suslu, Ahmet Emre; Funda, Yasemin Ongun; Sereflican, Murat
    Objective: In this study we aimed to investigate the psychological status of tinnitus patients as well as the sleep quality and their relation to handicap caused by tinnitus using various scales. Additionally, serum melatonin levels and the effectiveness of melatonin treatment were studied. Study Design: Prospective, double blind, randomized controlled trial Materials and Methods: Patients were divided randomly into two groups as study (melatonin, n=13) and placebo (control, n=11) groups. Tinnitus Handicap Inventory (THI), Symptom Check List (SCL), Hospital Anxiety and Depression Scale (HAD), Beck Depression Inventory (BDI), Pittsburg Sleep Quality Index (PSQI) were applied. After filling the scales and giving the venous blood sample for melatonin measurements the patients were instructed to take one tablet (placebo or 3 mg melatonin) before sleep every night. After 8 weeks, second order scales were filled and melatonin measurements were repeated. Results: Serum melatonin levels were between 1-260 pg/ml; the mean was 38,7 pg/ml. The correlation of melatonin levels with THI and tinnitus duration was not significant. THI was found to correlate with different measures of the PSQI, HAD, and BDI in both groups. Statistical analysis failed to show any significant difference within and between groups in respect of anxiety, depressive symptoms and sleep as well as melatonin and handicap levels. When the groups were assessed according to the THI severity (mild/moderate to severe;THI 2); in the control group there was significant differences in PSQI 1 and PSQI 1 (p=0.0008, p=0.18), HAD 1, HAD 2 (0.002, 0.03), HAD Depression 1-2 (0.0, 0.006) BDI (p=0.007) PSQI 2 sleep disturbance (p=0.018) parameters. However, in the melatonin group it was found that there were significant differences in SCL 2 sleep latency, PSQI 2 sleep duration and total PSQI 2 parameters. (p=0.022, 0.027, 0.006 respectively)Conclusion: Patients with higher handicap may benefit melatonin in respect of sleep latency and duration as well as sleep quality comparing with the patients taking placebo. Moreover, melatonin efficiency may be related to its antidepressive effect. © 2005 The Mediterranean Society of Otology and Audiology.
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    The Effects of Mistletoe (Viscum album L. subsp album) Extracts on Isolated Intestinal Contractions
    (Tubitak Scientific & Technological Research Council Turkey, 2008) Karakas, Alper; Serin, Erdinc; Guenduez, Buelent; Tuerker, Arzu Ucar
    Throughout history folk medicine has served as an alternative or complimentary method of treating disorders like intestinal colic. Mistletoe is a common name for many species of semi-parasitic plants that grow on trees throughout the world, and has been used widely to treat intestinal colic. We conducted a study to evaluate the effect of freeze-dried (group I) and heat-treated (group 2) extracts of Viscum album subsp. album leaves on contractions induced by acetylcholine in isolated hamster intestinal segments (duodenum, jejunum, and ileum). Freeze-dried extracts decreased intestinal contractions in all the intestinal segments (P < 0.05). The strongest relaxant effect was observed in the jejunum and the weakest was seen in the duodenum. Higher doses of heat-treated extracts were required to affect segmental contractions than that of freeze-dried extracts (P < 0.05): heat-treated extracts had the greatest effect on reducing contractions in the jejunum and the least effect in the duodenum. Mistletoe extracts affected the level of contractions in a dose- and extraction preparation-dependent manner. The results of this study show that mistletoe extracts could be effective against intestinal motility problems and that they have potential use as a therapeutic remedy for intestinal colic.
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    RELATIONSHIP OF HYPERLRICEMIA WITH LIPID PROFILES IN ELDERLY SUBJECTS
    (Nobel Ilac, 2006) Bugdayci, Guler; Serin, Erdinc
    Background : Hyperuricemia is a common finding in elderly people and more attention should be paid to the close relationship between hyperuricemia and hypcnipidemia. Aim : The purpose of this study was to determine the relationship between serum uric acid and lipid profile in eiderly subjects. Material and Methods : This study was performed to compare serum lipid levels elderly normouricemic subjects (controls, n=48, 25 male, 71.75 +/- 5.00 years) and in elderly hyperuricemic subjects (n = 42, 18 male, 72.19 +/- 5.08 years). Results : Serum total cholesterol (respectively, 202 +/- 40 mg/dl 173 +/- 36 mg/dl, p=0.0001), triglycerides (respectively, 130 +/- 51 mg/dl, 100 +/- 38 mg/dl, p=0.002) and LDL-cholesterol levels (respectively, 137 +/- 32 mg/dl, 106 +/- 26 mg/dl, p=0.001), were significantly higher and HDL-cholesterol level (respectively, 39 +/- 9 mg/dl, 46 +/- 13 mg/dl, p-0.008), was significantly lower in elderly subjects with hyperuricemia compared to hyperuricemia group. Conclusion : Hyperuricema is associated with hyperlipidemia in elderly patients.