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    The effect of melatonin on tinnitus with respect to sleep and depression: A randomized clinical trial
    (2012) Koybasi, Serap; Boztas, M. Hamid; Bicer, Yusuf Ozgur; Serin, Erdinc; Suslu, Ahmet Emre; Funda, Yasemin Ongun; Sereflican, Murat
    Objective: In this study we aimed to investigate the psychological status of tinnitus patients as well as the sleep quality and their relation to handicap caused by tinnitus using various scales. Additionally, serum melatonin levels and the effectiveness of melatonin treatment were studied. Study Design: Prospective, double blind, randomized controlled trial Materials and Methods: Patients were divided randomly into two groups as study (melatonin, n=13) and placebo (control, n=11) groups. Tinnitus Handicap Inventory (THI), Symptom Check List (SCL), Hospital Anxiety and Depression Scale (HAD), Beck Depression Inventory (BDI), Pittsburg Sleep Quality Index (PSQI) were applied. After filling the scales and giving the venous blood sample for melatonin measurements the patients were instructed to take one tablet (placebo or 3 mg melatonin) before sleep every night. After 8 weeks, second order scales were filled and melatonin measurements were repeated. Results: Serum melatonin levels were between 1-260 pg/ml; the mean was 38,7 pg/ml. The correlation of melatonin levels with THI and tinnitus duration was not significant. THI was found to correlate with different measures of the PSQI, HAD, and BDI in both groups. Statistical analysis failed to show any significant difference within and between groups in respect of anxiety, depressive symptoms and sleep as well as melatonin and handicap levels. When the groups were assessed according to the THI severity (mild/moderate to severe;THI 2); in the control group there was significant differences in PSQI 1 and PSQI 1 (p=0.0008, p=0.18), HAD 1, HAD 2 (0.002, 0.03), HAD Depression 1-2 (0.0, 0.006) BDI (p=0.007) PSQI 2 sleep disturbance (p=0.018) parameters. However, in the melatonin group it was found that there were significant differences in SCL 2 sleep latency, PSQI 2 sleep duration and total PSQI 2 parameters. (p=0.022, 0.027, 0.006 respectively)Conclusion: Patients with higher handicap may benefit melatonin in respect of sleep latency and duration as well as sleep quality comparing with the patients taking placebo. Moreover, melatonin efficiency may be related to its antidepressive effect. © 2005 The Mediterranean Society of Otology and Audiology.
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    Evaluation of olfactory memory after sevoflurane anesthesia: Is really short-term memory influenced?
    (Scientific Publishers of India, 2016) Bayir, Hakan; Yildiz, Isa; Yoldas, Hamit; Karagöz, İbrahim; Kurt, Adem Deniz; Kocoglu, Hasan; Sereflican, Murat
    Objective: Olfactory disorders can negatively effect the quality of life. Few clinical studies and case reports have investigated the relationship between anesthesia and olfactory dysfunction. The aim of this study was to investigate the effect of sevoflurane on olfactory memory with Brief-Smell Identification Test™ in patients used sevoflurane. Patients and Methods: This, prospective, clinical study was performed on 60 ASA physical status I-II patients, between 18-65 years of age who were scheduled for expected surgery duration of 40-120 minutes. All patients were preoperatively informed about Brief-Smell Identification Test. For induction 2 mg.kg-1propofol, 0.5 mg.kg-1 rocuronium and 1 ?g.kg-1 iv fentanyl were administered. Anesthesia was maintained with the inhalational of anesthetic sevoflurane (2%). Brief-Smell Identification Test scores are recorded 30 minutes before the surgery and when the Aldrate Recovery Score reached 10 in the postoperative period. Preoperative and postoperative results were compared and p-values<0.05 were considered statistically significant. Results: The patients mean age were 47.1 ± 13.8. There was no statistically significant difference between the mean preoperative and intraoperative HR and MAP values. Preoperative total correct answer rate to odorous substances was 85.4%, and postoperative rate was 84.5%. Percentage of the odor identification by the patients revealed no statistically significant difference when pre and post-operative rates were compared (P>0.05). © 2016, Scientific Publishers of India. All rights reserved.