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Öğe A convenient strategy for the synthesis of ?,?-unsaturated aldehydes and acids. a construction of skipped dienes(Pergamon-Elsevier Science Ltd, 1999) Saha, Goutam; Basu, Manas K.; Kim, Seongjin; Jung, Young-Ju; Adıyaman, MustafaA novel strategy is described for the synthesis of beta,gamma-unsaturated aldehydes which are the useful synthons for the synthesis of arachidonic acid and other eicosanoid products. These beta,gamma-unsaturated aldehydes have been used in the total synthesis of arachidonic acid.Öğe A new method for the preparation of olefins from vicinal diols(Pergamon-Elsevier Science Ltd, 1999) Adıyaman, Mustafa; Jung, Young-Ju; Kim, Seongjin; Saha, Goutam; Powell, William S.; FitzGerald, Garret A.; Rokach, JoshuaA novel method is reported for the transformation of vicinal diols to olefins. This methodology consists in the conversion of iodothiocarbonates such as 16 to olefin 17 with phenyl lithium in excellent yield. Compounds 7 and 12 were prepared by this methodology in order to determine if they would be recognized by the enzymes, 5-lipoxygenase and 15-lipoxygenase, respectively.