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Öğe HFE mutations analysis of Turkish patients with nonalcoholic steatohepatitis(Springer, 2006) Şimşek, Halis; Balaban, Hatice Yasemin; Sümer, Hale; Yılmaz, Engin; Tatar, GoncaChronic liver disease is a well-known cause of secondary iron overloading. Iron overloading of liver is associated with severity of fibrosis and increased risk for hepatocellular carcinoma as well as resistance to antiviral treatment. Iron content of liver in nonalcoholic steatohepatitis (NASH) patients is important because NASH causes chronic hepatitis, and there is also a debate on the role of iron for the pathogenesis of NASH.