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Öğe Chronic hepatitis B associated with hepatic steatosis, insulin resistance, necroinflammation and fibrosis(Makerere Univ, Fac Med, 2015) Yılmaz, Bülent; Köklü, Seyfettin; Büyükbayram, Hüseyin; Yalçın, Kendal; Korkmaz, Uğur; Poşul, Emrah; Can, Güray; Kurt, MevlütBackground: The effect of hepatitis B virus (HBV) infection on fatty liver disease is unclear.. Objectives: The aim of this study was to investigate the viral and host causes of fatty liver in chronic hepatitis B (CHB) patients. This study included 88 CHB patients of which 17 were not treated. Liver biopsy was performed in each patient. Group 1 included those with hepatic steatosis (n=28) and group 2 those without hepatic steatosis. The groups were compared in terms of age, body mass index (BMI), Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), viral load, biochemical parameters and histological findings. Patients in group 1 were subdivided according to the degree of steatosis as follows: grade 1 (15 patients, 53.6%), grade 2 (6 patients, 21.4%), and grade 3 (7 patients, 25%). Results: In group 1 (n=28), mean age, BMI, cholesterol, and HOMA-IR were found to be significantly higher than in group 2 (n=60). There were no significant differences in the positivity of viral load, HbeAg, treatment, fibrosis and other laboratory parameters between the two groups. HOMA-IR was the only independent predictive factor of liver steatosis in patients with CHB in logistic regression analysis. Conclusion: Hepatic steatosis in CHB patients was associated with host metabolic factors.Öğe Diffuse gastric mantle cell lymphoma resembling gastrointestinal stromal tumors(Mosby Inc., 2014) Yılmaz, Bülent; Poşul, Emrah; Çöl, Cavit; Üyetürk, Ümmügül; Boran, Çetin; Aktaş, Gülan; Kurt, MevlütAn 81-year-old man was admitted to our gastroenterology unit because of anemia. He had experienced anorexia, nausea, fatigue, and weight loss (6 kg) during the past 4 months. The results of physical examination were unremarkable; there was no lymphadenopathy, hepatosplenomegaly, or palpable abdominal mass.Öğe Does neutrophil-to-lymphocyte ratio predict active ulcerative colitis?(Springer Wien, 2015) Poşul, Emrah; Yılmaz, Bülent; Aktaş, Gülali; Kurt, MevlütBackground Inflammatory markers have been studied in ulcerative colitis (UC) for diagnosis, disease activity, and prediction of relapse. Blood neutrophil-to-lymphocyte (N/L) ratio has been used to determine outcomes of some malignancies and coronary artery disease. Blood N/L ratio is a simple sign of clinical inflammation. In this study, we examined N/L ratio in recurrent patients suffering from UC. Methods The aim of the present study was to analyze N/L ratios in serum samples of UC patients in remission and active phases. Patients' age, extend of the disease, disease duration, disease activity, drug, and other medical history were all noted for patients. C-reactive protein, erythrocyte sedimentation rate, and complete blood count were determined for patients. Results Forty-nine UC patients were admitted into the present study. The blood N/L ratios were significantly increased in active phase compared with inactive UC patients (p < 0.05). The cut-off value for N/L ratio for the detection of active UC patients was calculated as >= 2.3 using receiver operating characteristic analysis [sensitivity: 61.2 %, specificity: 66.7 %, AUC: 0.650 (0.540-0.760), p = 0.01]. Conclusions Present study shows that in patients with UC, the blood N/L ratio is associated with active disease. N/L ratio may be used as an activity parameter in UC.Öğe Endoscopic removal of gastric bezoars : an easy technique(Mosby-Elsevier, 2014) Kurt, Mevlüt; Poşul, Emrah; Yılmaz, Bülent; Korkmaz, UğurÖğe Epidemiologic features of inflammatory bowel disease in Western Blacksea region of Turkey for the last 10 years: Retrospective cohort study(Korean Assoc Internal Medicine, 2019) Can, Güray; Poşul, Emrah; Yılmaz, Bülent; Can, Hatice; Korkmaz, Uğur; Ermiş, FatihBackground/Aims: There are only a few epidemiological study about inflammatory bowel disease in the last 10 years in Turkey, especially in Western Blacksea region. In our study, we aimed to identify the changes in the incidence and the prevalence of inflammatory bowel disease in Western Blacksea region at the last 10 years. Methods: Totally 223 patients with inflammatory bowel disease (160 ulcerative colitis, 63 Crohn's disease) were enrolled in the study followed up between 2004 to 2013 years. The epidemiological characteristics of patients were recorded. Results: The prevalences were 12.53/10(5) and 31.83/10(5) for Crohn's disease and ulcerative colitis respectively. Mean annual incidences increased from 0.99/10(5) and 0.45/10(5) for ulcerative colitis and Crohn's disease (2004 to 2005 years) to 4.87/10(5) and 2.09/10(5) for ulcerative colitis and Crohn's disease respectively (2011 to 2013 years). While the prevalence was higher in urban areas in Crohn's disease (12.60/10(5)), it was higher in rural areas in ulcerative colitis (36.17/10(5)). In ulcerative colitis, mean annual incidences were 2.91/10(5) and 2.86/10(5) for urban and rural areas respectively. In Crohn's disease, they were 1.37/10(5) and 1.08/10(5) for urban and rural areas respectively. Conclusions: The incidence of inflammatory bowel disease seems to increase in Western Blacksea region at the last 10 years. This increment is more prevalent in rural areas.Öğe Ileum and colon perforations in a young patient with Behcet's disease(Aves, 2015) Kurt, Şule; Poşul, Emrah; Can, Güray; Şit, Mustafa; Yılmaz, Bülent; Korkmaz, Uğur; Kurt, MevlütÖğe A rare case of large cell lung carcinoma with gastric metastasis(2015) Yılmaz, Bülent; Can, Güray; Poşul, Emrah; Kar, Özlem Kurt; Yüksel, Coşkun; Boran, Çetin; Kilitçi, AsumanLung cancer (LC) is the leading reason of death from cancer the world-wide. It is usually silent, and about %50 have extra-thoracic metastasis the initial diagnosis.Öğe Rare complication of upper gastrointestinal endoscopy : bilateral swelling of parotid glands(Univ Catholique Louvain-Ucl, 2014) Can, Güray; Yiımaz, Bülent; Poşul, Emrah; Taslamacıoğlu, Tuba; Korkmaz, Uğur; Kurt, MevlütÖğe Removal of appendiceal fecalith with colonoscopy(Gazi Univ, Fac Med, 2016) Kurt, Mevlüt; Poşul, Emrah; Can, Güray; Yılmaz, Bülent; Korkmaz, UğurIt is generally accepted that fecalith is the main reason of acute appendicitis. In this report, we represented a case that established a fecalith in the appendicial lumen at the colonoscopic investigation. Clinical features of the patient have resolved after removal of the appendicular fecalith with colonoscopy. Patient was prevented from probable appendicitis, which will develop, with colonoscopic intervention.Öğe Tetany with hypomagnesemia, hypokalemia, and hypocalcemia as initial presentation of celiac disease(Lippincott Williams & Wilkins, 2018) Poşul, Emrah; Can, Güray; Tekelioğlu, Vildan; Yılmaz, Bülent; Korkmaz, Uğur; Özyalvaçlı, Gülzade; Kilitçi, Asuman; Kurt, MevlütCeliac disease is a systemic immune-mediated disorder that occurs after the ingestion of gluten in genetically susceptible individuals. It is caused by a combination of genetic and environmental factors. The illness is often accompanied by extraintestinal complications including osteopenia to osteoporosis. Tetany, a very rare existing feature of celiac disease, is caused by severe hypocalcemia as a result of intestinal calcium malabsorption. Hypomagnesemia may be seen in the setting of diarrhea, malabsorption, and steatorrhea. Clinical features include neuromuscular hyperexcitability (tremor, tetany, seizures) and arrhythmias that are often due to accompanying hypokalemia, hypomagnesemia, and hypocalcemia. We aimed to represent a case of celiac disease with tetany as initial presentation.Öğe Thyroid hematoma: an unusual complication of upper gastrointestinal endoscopy(Lippincott Williams & Wilkins, 2017) Poşul, Emrah; Can, Öznur; Akın, Büşra; Kurt, MevlütHere, we present a case of a patient who developed thyroid hematoma after upper gastrointestinal (GI) endoscopy without premedication except oral lidocaine spray. A 38-year-old man was admitted to our hospital with epigastric pain for the past 1 month. Upper GI endoscopy revealed antral gastritis, a 7-mm ulcer in the apical and a 6-mm ulcer in the posterior wall of the duodenal bulb. Pantoprazole 40 mg was given once daily. Two days later, he presented with an acute swelling of his neck. On examination, a large, nonfluctuant thyroid swelling was seen on the right side of the neck. His blood pressure, temperature, pulse rate, and respiratory rate were normal. Blood tests showed normal hemoglobin, international normalized ratio, and thyroid function tests. Ultrasonography of the neck revealed a 23 ×37 ×44-mm expanding hematoma located at the right thyroid gland.
