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    Is there any relationship between serum ?-glutamyltransferase levels and premature coronary artery disease?
    (Termedia Publishing House Ltd, 2012) Ozlu, Mehmet Fatih; Ayhan, Suzi Selim; Erdem, Alim; Tosun, Mehmet; Ozturk, Serkan; Erdem, Kemalettin; Ozyasar, Mehmet
    Background: The relationship between gamma-glutamyltransferase (GGT) and coronary artery disease (CAD) has been revealed in several previous studies. However, the relationship between the severity of CAD and GGT levels has not been previously studied in a premature group (< 40 years old). Aim: We aim to investigate whether GGT is associated with premature CAD. Material and methods: The study population consisted of 181 premature coronary artery disease patients (group 1; mean age: 36.5 +/- 2.5 years) and 80 controls (group 2; mean age: 37.2 +/- 2.3 years). The severity of CAD in group 1 was evaluated by the Gensini scoring system. gamma-Glutamyltransferase levels and the other basic biochemical parameters were analyzed, and relations with severity of CAD were evaluated. Results: There were no statistically significant differences in serum GGT activity between the two groups (p > 0.05). gamma-Glutamyltransferase levels in group 1 were found not to be correlated with the severity of premature CAD (r = -0.016, p = 0.828). Furthermore, in subgroup analyses we found glycated hemoglobin (HbA(1c)) levels significantly correlated with the severity of CAD in diabetic premature CAD patients, but not GGT (r = 0.448, p < 0.001; r = 0.157, p = 0.127, respectively). Conclusions: gamma-Glutamyltransferase level was not associated with severity of CAD in the premature group. Possibly, there is no predictive importance of GGT in patients with premature CAD.
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    Relation of neutrophil/lymphocyte ratio with the presence and extent of coronary artery ectasia
    (Turkish Soc Cardiology, 2013) Ayhan, Selim; Ozturk, Serkan; Erdem, Alim; Ozlu, Mehmet Fatih; Ozyasar, Mehmet; Erdem, Kemalettin; Yazici, Mehmet
    Objectives: It has been shown that the neutrophil to lymphocyte ratio (N/L ratio) is associated with cardiovascular events and mortality. In this study, we investigated the N/L ratio in patients with coronary artery ectasia (CAE). Study design: Fifty patients (29 men, 21 women; mean age, 51.1+/-7.1 years) diagnosed as CAE using coronary angiography were included in the study. The control group consisted of 28 patients (16 men, 12 women; mean age, 49.5+/-9.4 years) who had normal coronary arteries as determined by coronary angiography. Baseline characteristics were recorded. The number of ectatic segments was noted. Hematologic parameters were measured and the N/L ratio was calculated. Results: The N/L ratio was significantly higher in the CAE group compared with the control group (median [25-75% percentile] 2.2 [1.6-3.0] vs. 1.8 [1.4-2.0], p=0.014, respectively). The Spearman correlation analysis demonstrated that the N/L ratio positively
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    Relationship between plasma omentin-1 levels and newly diagnosed Stage I hypertension
    (Bayrakol Medical Publisher, 2022) Ozyasar, Mehmet; Erdem, Alim
    Aim: Omentin-1 is an adipose tissue-derived cytokine with unknown biological function. The impact of omentin-1 on hypertension has been questioned due to its relation to obesity. This study is aimed to investigate omentin-1 levels in hypertensive patients.Material and Methods: A prospective, case-control study evaluated patients admitted to outpatient cardiology clinics between January 2012 and December 2013. We designed two groups: the patient group comprised hypertensive patients with newly diagnosed stage-1 hypertension, and the control group comprised normotensive patients. The demographic and anthropometric characteristics and laboratory parameters of the patients in both groups were recorded. Plasma levels of omentin-1 were the primary outcome in this study. Results: Patient group consisted of 52 hypertensive patients, whereas the control group consisted of 36 patients without hypertension. There was no significant difference between the groups in terms of demographic and clinical characteristics (p>0.05). The median omentin-1 level of the patient group was higher than that of the control group (756.2 ng/mL vs. 664.4 ng/mL); however, the difference was insignificant (p=0.161).Discussion: The findings of this study did not suggest a significant relationship between the plasma omentin-1 levels and the newly diagnosed Stage hypertension.