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Bioassay guided fractionation of extracts from flowers of Bellis perennis L. for their anticancer activity
(Georg Thieme Verlag Kg, 2011) Karakaş, Pehlivan Fatma; Karakaş, Alper; Mshvildadze, V; Legault, J.; Pichette, A.; Türker, Uçar Arzu
Common daisy (Bellis perennis L.) is a member of the cosmopolitan family Compositae (Asteraceae). It is native to western, central, and northern Europe, but is commonly found as an invasive plant in North America (1). B. perennis has been used in the treatment of gastritis, enteritis, diarrhoea, bleeding, rheumatism, inflammation and infections of the upper respiratory tract (2–3). In this study, anticancer activity of crude hexane, dichloromethane, methanol, water extracts, also n-butanol and ethylacetate fractions (after separation of methanol extract) of flowers from Bellis perennis were investigated. Cytotoxic activities were carried out on human lung cancer (A549), human colorectal cancer (DLD-1), and normal skin fibroblasts (WS1) using the resazurin reduction test. Following the bioassay guided fractionation, the most active methanolic extract, was treated by n-butanol and ethylacetate. The n-butanolic fraction was found to be the most active against A-549 lung carcinoma and DLD-1 colon carcinoma cells, with IC50 values of 16±3 and 10±2µg/ml, respectively. The hexane, dichloromethane and water extracts did not show any significant activity against A-549 and DLD-1.